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N-Ethylaniline

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N-Ethylaniline Basic information

Product Name:
N-Ethylaniline
Synonyms:
  • Aethylanilin
  • Aniline, N-ethyl-
  • Ethylaniline
  • N-EthylaniIine
  • n-ethyl-anilin
  • n-ethyl-benzenamin
  • N-Ethylbenzenamine
  • N-ethyl-Benzenamine
CAS:
103-69-5
MF:
C8H11N
MW:
121.18
EINECS:
203-135-5
Product Categories:
  • Indazoles
  • organic chemical
  • Intermediates of Dyes and Pigments
Mol File:
103-69-5.mol
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N-Ethylaniline Chemical Properties

Melting point:
-63 °C
Boiling point:
205 °C(lit.)
Density 
0.963 g/mL at 25 °C(lit.)
vapor density 
4.2 (vs air)
vapor pressure 
0.2 mm Hg ( 25 °C)
refractive index 
n20/D 1.554(lit.)
Flash point:
185 °F
storage temp. 
Store below +30°C.
solubility 
2.7g/l
pka
5.12(at 24℃)
form 
Liquid
color 
Clear light yellow to light brown
PH
11 (2.7g/l, H2O, 20℃)
explosive limit
1.8-10.0%(V)
Water Solubility 
50 g/L (20 ºC)
Sensitive 
Air & Light Sensitive
Merck 
14,3764
BRN 
507468
Stability:
Stable, but decomposes upon prolonged exposure to air or light. Combustible. Incompatible with strong oxidizing agents. May react violently with nitric acid.
CAS DataBase Reference
103-69-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, N-ethyl-(103-69-5)
EPA Substance Registry System
N-Ethylaniline (103-69-5)
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25-33
Safety Statements 
28-37-45-28A
RIDADR 
UN 2272 6.1/PG 3
WGK Germany 
1
RTECS 
BX9780000
8
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
Hazardous Substances Data
103-69-5(Hazardous Substances Data)
Toxicity
LD50 in rats (g/kg): 0.18 i.p., 0.28 orally, 4.7 s.c. (Sziza, Podhragyai)

MSDS

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N-Ethylaniline Usage And Synthesis

Chemical Properties

yellow liquid

Chemical Properties

N-Ethylaniline is yellow-brown oil with a weak fishy odor.

Occurrence

Polyethylene bottles used in intravenous solutions have been reported to be contaminated with N-ethylaniline from rubber parts of the closure (Ulsaker and Teien 1979). It has been reported that rubber containing N,N,-dithiodimorpholine accelerator of vulcanization can release N-ethylaniline into an aqueous media (Stankevich and Shurupova 1976). This compound has also been reported as a contaminant of cigarette smoke at a level of 55.8 ng per one U.S. 85 mm cigarette (Patrianakos and Hoffmann 1979).

Uses

N-Ethylaniline is used as an explosive stabilizer and in dyestuff manufacture.

Uses

Organic synthesis.

Production Methods

Manufacture of N-ethylaniline is based on the reaction of aniline with alkyl halide or by heating aniline with ethyl alcohol under acidic conditions followed by purification (Windholz et al 1983).

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 4778, 1956 DOI: 10.1021/ja01599a063
The Journal of Organic Chemistry, 21, p. 988, 1956
Tetrahedron Letters, 25, p. 1635, 1984 DOI: 10.1016/S0040-4039(01)81131-X

General Description

A dark liquid with an aromatic odor. Insoluble in water. Density 0.963 g / cm3. Toxic by skin absorption and inhalation of vapors. Evolves toxic fumes during combustion. Flash point 185°F.

Air & Water Reactions

Unstable to prolonged exposure to air and/or light. Insoluble in water.

Reactivity Profile

N-Ethylaniline may react violently with nitric acid. May react with strong oxidizing agents. . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Toxic by ingestion, inhalation, and skin absorption.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Health Hazard

N-Ethylaniline is considered very hazardous in a fire situation, since it is highly toxic and readily absorbed by the inhalation, dermal and oral routes (HSDB 1988). Excessive exposure causes respiratory paralysis.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Industrial uses

N-Ethylaniline is used as an explosives stabilizer and as an intermediate in the manufacturing of dyes and pharmaceuticals (Northcott 1978).

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by an unspecified route. Mddly toxic by skin contact. An allergen. Flammable when exposed to heat or flame; can react with oxidizing materials. To fight fire, use dry chemical, CO2, foam. Hypergolic reaction with red fuming nitric acid. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of aniline and NOx.

Potential Exposure

This material is used as an intermediate in dyes, pharmaceuticals and explosives; in organic synthesis.

Metabolism

The metabolism of N-ethylaniline has been studied more as a tool to understanding microsomal drug metabolizing activity than as the central item of inquiry. However, the following have been clearly defined as metabolic products of N-ethylaniline: phenylhydroxylamine, N-hydroxyl, N-ethylaniline; N-ethyl-p-aminophenol; and aniline (Appel et al 1965; Heinze 1970; Hlavica 1970; Hlavica and Kiese 1969; Kampffmeyer and Kiese 1965; Kroeber et al 1970; Lange 1967 and Lange 1968). Nonmicrosomal metabolism has not been reported. Species shown capable of metabolism include rabbit, mouse, rat, dog, pig, and guinea pig with the proportions of the various metabolites often species dependent. Compounds similar to N-ethylaniline such as N-methyl-N-ethylaniline can form N-ethylaniline via demethylation (Gorrod et al 1975a,b).

Shipping

UN2272 N-Ethylaniline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Incompatibilities

May form explosive mixture with air. Decomposes on contact with light or air. Reacts with many materials. Neutralizes acids in exothermic reactions to form salts plus water. Flammable gaseous hydrogen may be generated in combination with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Contact with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials; strong acids, such as nitric acid, can cause fire; explosions with formation of toxic vapors of aniline and oxides of nitrogen; strong bases, isocyanates, halogenated organics, phenols (acidic), epoxides, anhydrides, and acid halides

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