Trichloroacetyl chloride Chemical Properties

Melting point:

-57 °C

Boiling point:

114-116 °C(lit.)

Density 

1.629 g/mL at 25 °C(lit.)

vapor pressure 

16 mm Hg ( 20 °C)

refractive index 

n20/D 1.470(lit.)

Flash point:

100 °C

storage temp. 

Refrigerator, Under inert atmosphere

solubility 

Chloroform (Soluble), Ethyl Acetate (Soluble)

form 

Oil

color 

Colourless

Water Solubility 

reacts violently

Sensitive 

Moisture Sensitive

BRN 

774120

Stability:

Stable. Reacts violently with water. Incompatible with alcohols, oxidizing agents, strong bases.

CAS DataBase Reference

76-02-8(CAS DataBase Reference)

NIST Chemistry Reference

Trichloroacetyl chloride(76-02-8)

EPA Substance Registry System

Trichloroacetyl chloride (76-02-8)

Safety Information

Hazard Codes 

T+,T

Risk Statements 

14-22-26-34-35-29

Safety Statements 

26-28-36/37/39-45-8-28A-23

RIDADR 

UN 2442 8/PG 2

WGK Germany 

3

RTECS 

AO7140000

F 

19

Hazard Note 

Very Toxic

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29159080

Hazardous Substances Data

76-02-8(Hazardous Substances Data)

MSDS

• Language:English Provider:Trichloroacetyl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Trichloroacetyl chloride Usage And Synthesis

Chemical Properties

Trichloroacetyl chloride is similar to dichloroacetyl chloride. It is a clear colourless liquid. Decomposes in water; soluble in alcohol.The acid chloride can be hydrolyzed at 75 – 85°C with water to form the free acid and hydrolyzed with ammonium hydroxide or concentrated sodium carbonate solution to form the salts.

Uses

Trichloroacetyl chloride can be used for the manufacture of the esters and the anhydrides of trichloroacetic acid.It was used in the preparation of dihydro-1H-benzindoles. It was also used in the synthesis of 3-alkylbenzoxazolones.

Uses

Trichloroacetyl Chloride is a reagent used to synthesize pyrazol-furan carboxamide analogues, which can act as Akt kinase inhibitors and pyrrolostatin, which can act as a lipid peroxidation inihibitor (1,2).

Preparation

The acetyl chloride is prepared from trichloroacetic acid and various inorganic acid chlorides (e.g., SOCl2, PCl3) or with P2O5 and HCl. More useful methods are the oxidation of tetrachloroethylene with fuming sulfuric acid, oxygen, or fuming nitric acid and sulfuric acid at 18-20°C, or from the reaction of pentachloroethane and dry oxygen under UV light. It has been obtained in 37 % yield from carbon tetrachloride and carbon monoxide in the presence of aluminum chloride at 200°C and high pressure.The most common production method is the gas-phase, photochemical oxidation of tetrachloroethylene with oxygen. The reaction is initiated with UV light, with radioactive irradiation, or it is sensitized with chlorine or iodine.

General Description

A colorless volatile liquid with a strong odor. Denser than water. Contact severely irritates skin, eyes and mucous membranes. May be very toxic by ingestion and inhalation. May be combustible.

Reactivity Profile

Trichloroacetyl chloride is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Highly toxic by ingestion and inhalation; strong irritant to skin and tissues.

Fire Hazard

Material may burn but does not ignite readily. Poisonous if inhaled or swallowed; skin contact poisonous. Contact may cause burns to skin and eyes.

Potential Exposure

Used in chemical syntheses.

Shipping

UN2442 Trichloroacetyl chloride, Hazard class: 8; Labels: 8-Corrosive material, 6.1-Poisonous materials.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, ethers and metal salts. Violent reaction with water, forming hydrochloric acid and trichloroacetic acid.

Waste Disposal

Do not discharge into drains or sewers. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices) Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Trichloroacetyl chloride(76-02-8)Related Product Information

• Potassium chloride
• Benzyloxyacetyl chloride
• 2,2,2-Trichloroacetamide
• Ammonium chloride
• Benzyl chloride
• Chloroacetyl chloride
• Phenoxyacetyl chloride
• Polyvinyl chloride
• Calcium chloride
• Trifluoroacetyl chloride
• Phenylacetyl chloride
• Choline chloride
• Acetyl chloride
• Sodium chloride
• Trichloroacetic acid
• CERIUM(III) CHLORIDE
• NEODYMIUM CHLORIDE
• Phosphorus oxychloride