2-Methylaminopyridine-3-carbaldehyde Chemical Properties

Boiling point:

281.7±25.0 °C(Predicted)

Density 

1.196±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

5.00±0.10(Predicted)

Appearance

Light yellow to brown Liquid

Safety Information

HazardClass 

IRRITANT

HS Code 

2933399990

2-Methylaminopyridine-3-carbaldehyde Usage And Synthesis

Uses

2-Methylamino-3-pyridinecarboxaldehyde is a pyridine derivative that can be used for the structural modification and derivatization of pyridine-containing drug molecules and bioactive molecules.

Synthesis

Preparation of 2-(Methylamino)nicotinaldehyde: 9.10 g (66.0 mmol) of 2-(methylamino)-3-pyridinemethanol was dissolved in 70 mL of chloroform and 17.4 g (200 mmol) of manganese dioxide was added. The reaction mixture was stirred at 60 °C overnight. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated to give 8.66 g (yield: 96%) of 2-(methylamino)nicotinaldehyde as an orange solid.NMR data (CDCl3/TMS, δ, ppm): 3.10 (3H, d), 6.62-6.66 (1H, m), 7.74 (1H, d), 8.36 (1H, d), 9.80 (1H, s).

References

[1] Patent: US2011/287937, 2011, A1. Location in patent: Page/Page column 69

2-Methylaminopyridine-3-carbaldehyde(32399-08-9)Related Product Information

• p-Anisaldehyde
• 3-Methoxybenzaldehyde
• 3-Aminopyridine
• 3-Pyridinecarboxaldehyde
• PHENYLGLYOXAL MONOHYDRATE
• o-Anisaldehyde
• Nalidixic acid
• FLUNIXIN MEGLUMINE
• Nalidixic acid sodium salt
• 2-(Methylamino)pyridine-3-carboxylic acid
• Niflumic acid
• Amfonelic acid
• Enoxacin
• 2-ANILINONICOTINIC ACID
• 4,6-DIMETHYL-2-(([3-(TRIFLUOROMETHYL)ANILINO]CARBONYL)AMINO)NICOTINAMIDE
• 4,6-DIMETHYL-2-(([4-(TRIFLUOROMETHOXY)ANILINO]CARBONYL)AMINO)NICOTINAMIDE
• 2-Methylaminopyridine-3-carbaldehyde
• pyridylaldehyde