ANGIOTENSIN I/II (5-8) Chemical Properties

Boiling point:

915.4±65.0 °C(Predicted)

Density 

1.286±0.06 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

Soluble in DMSO

pka

3.56±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

H-Ile-His-Pro-Phe-OH

ANGIOTENSIN I/II (5-8) Usage And Synthesis

Uses

Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[2][3].

Definition

ChEBI: Angiotensin (5-8) is a dichlorobenzene.

References

[1] Guethe LM, et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience. 2013 Feb 12;231:315-27. DOI:10.1016/j.neuroscience.2012.11.048
[2] De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. DOI:10.3389/fphys.2013.00411
[3] Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5. DOI:10.5049/EBP.2013.11.2.41

ANGIOTENSIN I/II (5-8)(34233-50-6)Related Product Information

• ANGIOTENSIN I HUMAN ACETATE HYDRATE
• ANGIOTENSIN 1/2 + A (2 - 8)
• ANGIOTENSIN III, HUMAN
• BZ-GLY-GLY-GLY-OH
• ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT
• ANGIOTENSIN I/II (3-7)
• ANGIOTENSIN I/II (4-8)
• ANGIOTENSIN III, HUMAN
• ANGIOTENSIN I/II (1-6)
• L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
• ASP-ARG-VAL-TYR
• (DES-ASP1,ILE8)-ANGIOTENSIN II
• Angiotensin
• NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla
• ANGIOTENSIN I/II (1-5)
• Angiogenin (108-122) TFA
• ANGIOTENSIN I, HUMAN
• H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH