L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- Chemical Properties

Density 

1.45±0.1 g/cm3(Predicted)

pka

3.56±0.10(Predicted)

form 

Solid

color 

White to off-white

L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- Usage And Synthesis

Uses

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].

IC 50

AT1 Receptor

References

[1] Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. DOI:10.1016/j.cell.2018.12.005

L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-(812644-79-4)Related Product Information

• ANGIOTENSIN I/II (4-8)
• ANGIOTENSIN III, HUMAN
• ANGIOTENSIN I/II (1-6)
• ASP-ARG-VAL-TYR
• (DES-ASP1,ILE8)-ANGIOTENSIN II
• Angiotensin
• ANGIOTENSIN I/II (3-7)
• NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla
• BZ-GLY-GLY-GLY-OH
• ANGIOTENSIN I/II (1-5)
• Angiogenin (108-122) TFA
• ANGIOTENSIN I, HUMAN
• H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH
• ANGIOTENSIN I/II (5-8)
• ANGIOTENSINOGEN (1-13) (HUMAN)
• (SAR1,ILE4,8)-ANGIOTENSIN II
• ANGIOTENSIN III, HUMAN
• ANGIOTENSIN 1/2 + A (2 - 8)