(S)-(+)-2-Amino-1-butanol Chemical Properties

Melting point:

-2 °C(lit.)

Boiling point:

179-183 °C(lit.)

alpha 

[α]D20 +9～+11° (neat)

Density 

0.944 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.4521(lit.)

Flash point:

184 °F

storage temp. 

2-8°C(protect from light)

solubility 

Soluble in water

form 

clear liquid

pka

pK1: 9.52(+1) (25°C)

color 

Clear colorless to slightly yellowish viscous liquid

optical activity

[α]20/D +10°, neat

Water Solubility 

1000g/L at 25℃

Sensitive 

Air Sensitive & Hygroscopic

BRN 

1718930

CAS DataBase Reference

5856-62-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34-37-22

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2735 8/PG 3

WGK Germany 

3

RTECS 

EK9625000

HazardClass 

8

PackingGroup 

III

HS Code 

29221990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(S)-(+)-2-Amino-1-butanol Usage And Synthesis

Chemical Properties

clear colorless to slightly yellowish viscous

Uses

(S)-(+)-2-Amino-1-butanol is a chiral amino alcohol that may be used in the synthesis of (S)-2-(6-benzylamino-9-isopropyl-9H-purin-2-ylamino) butan-1-ol, an (S)-enantiomer of roscovitine. It can also be used to synthesize homochiral 2-methylpyrroles. (S)-(+)-2-Amino-1-butanol is an intermediate for the synthesis of (S,S)-ethambutol, an antibacterial agent for treating tuberculosis.

Purification Methods

They are purified by shaking with solid NaOH, filtering and distilling through a short column. The oxalate of the racemate has m 176o. They are strong bases and should be stored under N2 in the absence of CO2. The enantiomers have [] 20 ±12.5o (c 2, EtOH). [Johnson & Degering J Org Chem 8 7 1943, Nagao et al. J Org Chem 51 2392 1986, Santaniello et al. J Chem Soc, Perkin Trans 1 919 1985, Beilstein 4 H 291, 4 IV 1705.]

(S)-(+)-2-Amino-1-butanol(5856-62-2)Related Product Information

• (R)-(-)-2-Amino-1-butanol
• (1R,3S,5R)-2-(tert-butoxycarbonyl)-5-methyl-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
• (R)-3-(4'-bromophenyl)-3-hydroxypropanenitrile
• tube1190
• tube1196
• Tris(2,2'-bipyridine)ruthenium dichloride
• tube1192
• tube1194
• tube1193
• Bis[(pentamethylcyclopentadienyl)dichloro-rhodium]
• (S)-3-(4'-bromophenyl)-3-hydroxypropanenitrile
• tube1195
• methyl (S)-4-((tert-butoxycarbonyl)amino)cyclopent-1-ene-1-carboxylate
• D-3-Bromocamphor-8-sulfonic acid ammonium salt
• Trimebutine maleate
• (R)-2-Methyl-4-amino-1-butanol,(R)-2-Methyl-4-amino-1-butanol
• 4-AMINO-2-BUTANOL
• 4-ETHYLAMINO-1-BUTANOL