Pexiganan
Pexiganan Basic information
- Product Name:
- Pexiganan
- Synonyms:
-
- Pexiganan Acetate
- L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-
- Pexiganan USP/EP/BP
- CAS:
- 147664-63-9
- MF:
- C122H210N32O22
- MW:
- 2477.17
- Mol File:
- 147664-63-9.mol
Pexiganan Chemical Properties
- Boiling point:
- 2261.8±65.0 °C(Predicted)
- Density
- 1.180±0.06 g/cm3(Predicted)
- form
- Solid
- color
- White to off-white
Pexiganan Usage And Synthesis
Uses
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections[1].
in vivo
Pexiganan (1, 3, 10 or 30 mg/kg, p.o., daily for three consecutive days) shows H. pylori clearance efficiency in H. pylori-infected mouse[3].
Pexiganan (1 mg/kg, i.p.) shows antimicrobial activity in rat models of Gram-negative septic shock[4].
| Animal Model: | H. pylori-infected mouse[3]. |
| Dosage: | 1, 3, 10 or 30 mg/kg |
| Administration: | Oral administration, daily for three consecutive days. |
| Result: | Lowered H. pylori urease activities in mouse stomachs. |
| Animal Model: | Rat models of Gram-negative septic shock (induced by E.coli ATCC 25922)[4]. |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Displayed antimicrobial activities and survival rates of 67.7%. |
References
[1] Lamb HM, et al. Pexiganan acetate. Drugs. 1998 Dec;56(6):1047-52; discussion 1053-4. DOI:10.2165/00003495-199856060-00011
[2] Ge Y, et al. In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother. 1999 Apr;43(4):782-8. DOI:10.1128/AAC.43.4.782
[3] Zhang XL, et al. The synthetic antimicrobial peptide pexiganan and its nanoparticles (PNPs) exhibit the anti-helicobacter pylori activity in vitro and in vivo. Molecules. 2015 Mar 2;20(3):3972-85. DOI:10.3390/molecules20033972
[4] Giacometti A, et al. Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock. Peptides. 2005 Feb;26(2):207-16. DOI:10.1016/j.peptides.2004.09.012
PexigananSupplier
- Tel
- 0510-85629785 18013409632
- sales@reading-chemicals.com
- Tel
- 17802107445
- Tel
- 17705183659
- sales@njleonbiotech.com
- Tel
- 025-58361106-805 15951641583
- zhao.xu@njpeptide.com
- Tel
- +86-17380623303
- Caroline@youngshechem.com