Basic information Safety Supplier Related

Abaloparatide

Basic information Safety Supplier Related

Abaloparatide Basic information

Product Name:
Abaloparatide
Synonyms:
  • Abaloparatide
  • Abaloparatide (BA058)
CAS:
247062-33-5
MF:
C174H300N56O49
MW:
3960.5896
Mol File:
247062-33-5.mol
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Abaloparatide Chemical Properties

form 
Solid
color 
White to off-white
Sequence
H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-N-Me-Ala-Lys-Leu-His-Thr-Ala-NH2
InChIKey
BVISQZFBLRSESR-XSCWXTNMSA-N
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Abaloparatide Usage And Synthesis

Description

Abaloparatide is a parathyroid hormone receptor 1 (PTHR1) analog and a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide is used to treat osteoporosis.

Uses

Abaloparatide, a synthetic peptide analog of parathyroid hormone-related protein (PTHrP), has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of osteoporosis in specific patient populations. The drug is indicated for postmenopausal women who are at a high risk of fracture, which can be defined by a history of osteoporotic fracture, multiple risk factors for fracture, or those who have failed or are intolerant to other available osteoporosis therapies. In addition to its use in postmenopausal women, abaloparatide has also been approved for increasing bone density in men with osteoporosis who are at high risk for fractures. This approval extends to adult patients who have not responded effectively to or cannot tolerate other osteoporosis treatments. The drug is designed to stimulate bone formation, thereby reducing the risk of fractures associated with osteoporosis.

Mechanism of action

Abaloparatide is a human parathyroid hormone-related peptide [PTHrP(1-34)] analog, which acts as an agonist at the PTH1 receptor (PTH1R). This results in activation of the cAMP signaling pathway in target cells. In rats and monkeys, abaloparatide had an anabolic effect on bone, demonstrated by increases in BMD and bone mineral content (BMC) that correlated with increases in bone strength at vertebral and/or nonvertebral site.

Side effects

Abaloparatide is well tolerated and has mild adverse effects. Patients may experience nausea, dizziness, headache, palpitations, and hypercalciuria. Abaloparatide has been associated with supraventricular extrasystoles and orthostatic hypotension. The common (≥5%) treatment-emergent adverse drug reactions in men with osteoporosis are injection site reactions, nasopharyngitis, arthralgia, bronchitis, and hypertension.
The adverse effects reported from a randomized, double-blind, placebo-controlled trial among postmenopausal women with osteoporosis receiving 80 mcg of abaloparatide daily for 18 months include hypercalcemia (11%), dizziness (10%), nausea (8%), headache (8%), palpitations (5%), fatigue (3%), upper abdominal pain (3%), and vertigo (2%).

AbaloparatideSupplier

Hangzhou Peptidego Biotech Co.,Ltd. Gold
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0571-87213919
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Eric@peptidego.com
Shaoxing Junyu Biotechnology Co., LTD Gold
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0571-88211921 15572296305
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sales4@gotopbio.com
Hubei Zhaoke BIO-CHEMICAL Co., Ltd. Gold
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18271904430
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1070737105@qq.com
Sichuan Takele Biotechnology Co., Ltd. Gold
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+86-028-64348587 15680781153
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sales@takelepeptide.com
Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com