protohypericin Chemical Properties

Boiling point:

954.3±65.0 °C(Predicted)

Density 

1.736±0.06 g/cm3(Predicted)

solubility 

DMSO: Sparingly Soluble: 1-10 mg/ml
Methanol: Sparingly Soluble: 1-10 mg/ml

form 

Solid

pka

5.63±0.20(Predicted)

color 

Purple to black

LogP

8.870 (est)

protohypericin Usage And Synthesis

Uses

Protohypericin is a naturally occurring naphthodianthrone derived from plant Hypericum perforatum. Radioiodinated protohypericin is used in Tumor necrosis targeted radiotherapy[1][2].

References

[1] Baugh SF. Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure. J AOAC Int. 2005 Nov-Dec;88(6):1607-12. PMID:16526439
[2] Liu X, et al. Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model. Oncotarget. 2015 Sep 22;6(28):26400-10. DOI:10.18632/oncotarget.4568
[3] GEORGIOS PIPEROPOULOS . Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography–electrospray mass spectrometry[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1997, 695 2: Pages 309-316. DOI: 10.1016/s0378-4347(97)00188-6
[4] E M DELAEY. Photocytotoxicity of protohypericin after photoconversion to hypericin.[J]. Planta medica, 1999, 65 8: 719-722. DOI: 10.1055/s-1999-14050

protohypericin(548-03-8)Related Product Information

• protopseudohypericin
• PROTOHYPERICIN Original Hypericin Standard
• HYPERFORIN
• Polysaccharide
• Hypericin
• Lotus Leaf Extract
• 1,3-DIHYDROXYNAPHTHALENE
• 2-HYDROXYANTHRACENE
• 1-HYDROXY-PHENANTHRENE
• Perylene
• Benz[a]anthracene
• 4-HYDROXY-PHENANTHRENE
• 2-methylbenz(a)anthracene
• BENZO(C)PHENANTHRENE
• 2-HYDROXY-PHENANTHRENE
• (5)HELICENE
• protohypericin
• BENZO(A)PERYLENE