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3-((2,2,2- trifluoroethyl)thio)aniline

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3-((2,2,2- trifluoroethyl)thio)aniline Basic information

Product Name:
3-((2,2,2- trifluoroethyl)thio)aniline
Synonyms:
  • CarolGold
  • Canthaxanthin Beadlet 10% CWS-S
  • Canthaxanthin Beadlet 10% TAB
  • CarolGold (Lutein) EMulsion
  • CarolGold (Lutein) Powder
  • Octadecane(OtBu)-Glu-OtBu
  • Octadecane(OtBu)-Glu(AEEA-AEEA-NHS)-OtBu
  • Boc-His(Trt)-Aib-Glu(OtBu)-Gly-NHS
CAS:
1445684-99-0
MF:
C8H8F3NS
MW:
207.22
EINECS:
000-000-0
Product Categories:
  • Antifungal
  • Plant extract
  • Extracted from Marigold
Mol File:
1445684-99-0.mol
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3-((2,2,2- trifluoroethyl)thio)aniline Chemical Properties

InChI
InChI=1S/C8H8F3NS/c9-8(10,11)5-13-7-3-1-2-6(12)4-7/h1-4H,5,12H2
InChIKey
KMYQCBMXXMOPSD-UHFFFAOYSA-N
SMILES
C1(N)=CC=CC(SCC(F)(F)F)=C1
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3-((2,2,2- trifluoroethyl)thio)aniline Usage And Synthesis

Uses

3-((2,2,2-trifluoroethyl)thio)aniline can be used as an intermediate in pharmaceutical research.

Synthesis

To a solution of 3-aminobenzenethiol (4.43 g, 35.4 mmol) in THF (225 mL) was added sodium hydride (1.77 g, 44.3 mmol) at 0 °C and stirred for 30 min. Then, 2,2,2-trifluoroethyl 4- methylbenzenesulfonate (9.0 g, 35.4 mmol) was added and the reaction mixture was stirred for 18 h. The reaction mixture was quenched with water (20 mL) and extracted with EtOAc (2x50 mL). The combined organic extracts were washed with water, dried over Na2SO4, fdtered, and concentrated under reduced pressure. The crude residue was purified by flash chromatography through a Redi-Sep pre-packed silica gel column, eluting with a gradient of 5 % to 10 % EtOAc in hexanes, to give 3-((2,2,2- trifluoroethyl)thio)aniline (5 g, 68 % yield) as a pale brown oil.

3-((2,2,2- trifluoroethyl)thio)anilineSupplier

Chengdu Pukang Biotechnology Co., Ltd
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Deyang Yuehe Bio-Pharmaceutical Co.,Ltd
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Taizhou GreenChem Pharmaceutical Co., Ltd.
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ATK CHEMICAL COMPANY LIMITED
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Tianjin Kailiqi Biotechnology Co., Ltd.
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