LEUKOTRIENE B4 Chemical Properties

Boiling point:

536.4±50.0 °C(Predicted)

Density 

1.040±0.06 g/cm3(Predicted)

Flash point:

14 °C

storage temp. 

-20°C

solubility 

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50μg/ml)

pka

4.66±0.10(Predicted)

form 

Clear oil

CAS DataBase Reference

71160-24-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

F

Risk Statements 

11

Safety Statements 

7-16

RIDADR 

UN 1170 3/PG 2

WGK Germany 

1

MSDS

• Language:English Provider:SigmaAldrich

LEUKOTRIENE B4 Usage And Synthesis

Description

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10⁻¹⁰ M), LTB₄ causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes. At higher concentrations, (1.0 x 10⁻⁷ M), LTB₄ leads to neutrophil aggregation and degranulation as well as superoxide anion production.

LTB₄ MaxSpec^® standard is a quantitative grade standard of LTB₄ that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTB₄ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

LTB4 (Leukotriene B4) is a potent chemokine with roles in inflammation, immunology, the nervous system, brain and skin.

Definition

ChEBI: A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.

Biological Activity

Potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT 1 and BLT 2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.

Biochem/physiol Actions

Proinflammatory agent. Stimulates c-Fos and c-Jun proto-oncogene transcription in human monocytes. Stimulates chemotaxis, aggregation, and degranulation of polymorphonuclear leukocytes.

storage

Store at -20°C

LEUKOTRIENE B4(71160-24-2)Related Product Information

• (5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID
• ANTI-LEUKOTRIENE B4 RECEPTOR 2,ANTI-LEUKOTRIENE B4 RECEPTOR BLT2
• CYSTEINYL-LEUKOTRIENE AFFINITY SORBENT
• 12-EPI LEUKOTRIENE B4
• 20-TRIFLUORO LEUKOTRIENE B4
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• 14,15-LEUKOTRIENE A4 METHYL ESTER
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• 6E-12-EPI-LEUKOTRIENE B4,6-TRANS-12-EPI LEUKOTRIENE B4
• LEUKOTRIENE A4 METHYL ESTER,(-)-LEUKOTRIENE A4 METHYL ESTER
• 6-TRANS LEUKOTRIENE B4
• 14,15-DEHYDRO LEUKOTRIENE B4
• 14,15-LEUKOTRIENE C4
• 11-TRANS LEUKOTRIENE C4