2-Iodoanisole Chemical Properties

Melting point:

588.5 °C

Boiling point:

125-126 °C19 mm Hg(lit.)

Density 

1.799 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.622(lit.)

Flash point:

>110°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

alcohol: miscible(lit.)

form 

Liquid

Specific Gravity

1.799

color 

Clear yellow

Water Solubility 

insoluble

Sensitive 

Light Sensitive

Merck 

14,5028

BRN 

1860243

InChI

1S/C7H7IO/c1-9-7-5-3-2-4-6(7)8/h2-5H,1H3

InChIKey

DVQWNQBEUKXONL-UHFFFAOYSA-N

SMILES

COc1ccccc1I

CAS DataBase Reference

529-28-2(CAS DataBase Reference)

NIST Chemistry Reference

2-Iodoanisole(529-28-2)

EPA Substance Registry System

Benzene, 1-iodo-2-methoxy- (529-28-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

8

TSCA 

TSCA listed

HS Code 

29093090

Storage Class

10 - Combustible liquids

MSDS

• Language:English Provider:2-Methoxyiodobenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Iodoanisole Usage And Synthesis

Chemical Properties

Clear yellow liquid

Uses

suzuki reaction

Uses

2-Iodoanisole has been used in palladium/copper-catalyzed synthesis of o-(1-alkynyl)anisoles.

Definition

ChEBI: An organoiodine compound that is iodobenzene substituted by methoxy group at psotion 2.

General Description

2-Iodoanisole participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.

Synthesis

(1) Prepare 2 moles of 20% NaI aqueous solution A and 2.1 moles of 8-10% sodium hypochlorite aqueous solution B for spare use;

(2) Add 900g of anisole in a 2L four-necked round-bottomed flask equipped with stirring, a temperature display, and two constant-pressure dropping funnels and heat it up to 60-70??C with stirring; then, dropwise add the sodium iodide solution and sodium hypochlorite solution simultaneously at the ratio of molar ratio 1:1.05 with stirring;

(3) After dropping and adding, warm it up to 75-80??C and get the light yellow reaction solution; cool it down to 75-80??C; and cool it down to 80%. Sodium iodide solution and sodium hypochlorite solution;

(3) after dropping, warm up to 75~80 ??, stirring for 1 hour, to get light yellow reaction solution; cooled to room temperature, static phase splitting; the organic phase washed with water, drying and filtration, to get the anisole solution of 2-iodoanisole, distillation, cooling, curing, to get the white lumpy crystals, i.e., 2-iodoanisole, whose content is ?? 98.5%, yield 93.4% .

2-Iodoanisole(529-28-2)Related Product Information

• Dimefluthrin
• Anisole
• 1,4-Diiodobenzene
• Dimethyl ether
• METHYL THIOPHENE-2-CARBOXYLATE
• Kresoxim-methyl
• 1-Bromo-4-iodobenzene
• Methylparaben
• 2-Iodobenzoic acid
• 1-Bromo-2-iodobenzene
• Bensulfuron methyl
• Methyl acrylate
• 1-Methoxy-2-propyl acetate
• Thiophanate-methyl
• 2-Iodotoluene
• (Diacetoxyiodo)benzene
• Methyl
• Parathion-methyl