ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > Serine derivatives > (2R,3S)-N-Benzoyl-3-phenyl Isoserine
(2R,3S)-N-Benzoyl-3-phenyl Isoserine
(2R,3S)-N-Benzoyl-3-phenyl Isoserine Basic information
- Product Name:
- (2R,3S)-N-Benzoyl-3-phenyl Isoserine
- Synonyms:
-
- N-BENZOYL-(2R,3S)-3-AMINO-2-HYDROXY-3-PHENYL-PROPIONIC ACID
- N-BENZOYL-(2R,3S)-3-PHENYLISOSERINE
- TAXOL(R) SIDE CHAIN
- (2R,3S)-3-Benzoylamino-2-Hydro
- (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionacid
- Taxol side chain alcohol
- (2R, 3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONACID,98+%
- (2R,3S)-3-Benzoylamino-2-hydroxy-3-phenylpropionic acid
- CAS:
- 132201-33-3
- MF:
- C16H15NO4
- MW:
- 285.3
- EINECS:
- 631-348-7
- Product Categories:
-
- Herb extract
- Serine Derivatives
- Peptide Synthesis
- Unnatural Amino Acid Derivatives
- Amino Acids & Derivatives
- Anti-virals
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 132201-33-3.mol
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(2R,3S)-N-Benzoyl-3-phenyl Isoserine Chemical Properties
- Melting point:
- 169-172 °C (lit.)
- Boiling point:
- 580.7±50.0 °C(Predicted)
- Density
- 1.316±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Ethanol (Slightly)
- form
- Solid
- pka
- 3.40±0.17(Predicted)
- color
- White to Off-White
- optical activity
- [α]20/D 40°, c = 1.0 in ethanol
- CAS DataBase Reference
- 132201-33-3(CAS DataBase Reference)
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MSDS
- Language:English Provider:SigmaAldrich
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(2R,3S)-N-Benzoyl-3-phenyl Isoserine Usage And Synthesis
Uses
(2R,3S)-N-Benzoyl-3-phenylisoserine is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites. (2R,3S)-N-Benzoyl-3-phenylisoserine shows cytotoxic, antiviral and immunomodulatory activity.
Uses
The presence of this chiral side chain has proven to be essential for the biological activity of taxol, one of the most promising anticancer agents being investigated. The challenging synthesis of taxol has stimulated interest in the attachment of the C-13 side chain to naturally derived taxanes like baccatin III.
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(2R,3S)-N-Benzoyl-3-phenyl Isoserine(132201-33-3)Related Product Information
- CHLOROPHOSPHONAZO III
- BENZOYL ISOCYANATE
- Benzoyl peroxide
- L-Homoserine
- Citric acid
- L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE
- 3-(4-Hydroxyphenyl)propionic acid
- Folic acid
- Benzoyl chloride
- Ethyl 2-(Chlorosulfonyl)acetate
- D-Cycloserine
- 3,4'-DIAMINODIPHENYLMETHANE
- L(+)-Lactic acid
- β-Alanine
- DL-Serine
- N-BENZOYL-(2R,3S)-3-PHENYLISOSERINE METHYL ESTER
- 7-Epitaxol
- 10-Deacetylbaccatin III