Tetrabutylammonium fluoride trihydrate Chemical Properties

Melting point:

62-63 °C(lit.)

Flash point:

-17℃

storage temp. 

Store below +30°C.

form 

Crystalline Powder, Crystals and/or Chunks

Specific Gravity

0.887

color 

White to slightly yellow

PH

pH (50g/l, 25℃) : 5.0～8.0

Water Solubility 

SOLUBLE

Sensitive 

Hygroscopic

BRN 

3761900

Exposure limits

ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3

InChI

InChI=1S/C16H36N.FH.H2O/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;;/h5-16H2,1-4H3;1H;1H2/q+1;;/p-1

InChIKey

UQCWXKSHRQJGPH-UHFFFAOYSA-M

SMILES

[N+](CCCC)(CCCC)(CCCC)CCCC.[F-].O

CAS DataBase Reference

87749-50-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/37/38

Safety Statements 

26-36/37/39-45-26 37/39

RIDADR 

UN 1759 8/PG 1

WGK Germany 

3

F 

3-10

Hazard Note 

Irritant

TSCA 

T

HazardClass 

6.1

PackingGroup 

II

HS Code 

38220000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tetrabutylammonium fluoride trihydrate Usage And Synthesis

Description

Tetrabutylammonium fluoride trihydrate is a commonly used salt within the realms of organic chemistry and biochemistry. This compound is employed as a potent base, finding extensive use in diverse applications, including organic compound synthesis, buffer preparation, and protein purification. It plays a pivotal role in the synthesis of various organic compounds, such as carboxylic acids, amines, and alcohols. Additionally, this compound facilitates the purification of nucleic acids, including DNA and RNA. Acting as a strong base, tetrabutylammonium fluoride trihydrate possesses the ability to deprotonate a wide range of organic compounds. It is commonly used in applications such as preparation of deprotecting agents, synthesis of lipophilic peprides during DNA transfections, and many more.

Chemical Properties

white crystals or crystalline powder

Uses

Reactant for:
Preparation of deprotecting agents in preparation of cellulose derivatives
Synthesis of lipophilic peptides for DNA transfections in vivo
Dehydrobromination reactions

General Description

Tetrabutylammonium fluoride trihydrate is a mild base used in reactions like aldol-type condensation reactions, Michael-type reactions, ring-opening reactions. Its is also used as a promoter in cross-coupling reactions and cyclization of carbocycles and heterocycles.

Tetrabutylammonium fluoride trihydrate(87749-50-6)Related Product Information

• TETRABUTYL AMMONIUM BROMIDE
• Tetrabutylammonium bromide
• Tributyltin chloride
• Tetrabutylammonium fluoride
• FLUORIDE STANDARD
• Ammonium fluoride
• Tetrabutylammonium hydroxide
• Tetrabutylammonium tribromide
• Tetrabutylammonium borohydride
• Tetrabutylammonium iodide
• Tetrabutylammonium hexafluorophosphate
• Tetrabutylammonium tetra (tert butyl alcohol) coordination fluoride
• Tetrabutylammonium phosphate
• Tetrabutylphosphonium fluoride
• Tetrapropylammonium hydroxide
• Tetrabutyl ammonium chloride
• Tetrabutylammonium acetate
• Tetrapropylammonium bromide