Basic information Description References Safety Supplier Related
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Tributyltin chloride

Basic information Description References Safety Supplier Related

Tributyltin chloride Basic information

Product Name:
Tributyltin chloride
Synonyms:
  • TBTC
  • N-TRI-TERT-BUTYLTIN CHLORIDE
  • CHLOROTRIBUTYLSTANNANE
  • CHLOROTRIBUTYLTIN
  • CHLOROTRI-N-BUTYLTIN
  • tributylchlorostannane
  • TRIBUTYLCHLOROTIN
  • TRIBUTYLTIN CHLORIDE
CAS:
1461-22-9
MF:
C12H27ClSn
MW:
325.51
EINECS:
215-958-7
Product Categories:
  • Organometallics
  • Alphabetical Listings
  • Tin Compound (Environmental Endocrine Disruptors)
  • Organometallic Reagents
  • Organotin
  • Organotin HalidesStable Isotopes
  • Alkyl Metals
  • Analytical Chemistry
  • Classes of Metal Compounds
  • Environmental Endocrine Disruptors
  • Grignard Reagents & Alkyl Metals
  • Sn (Tin) Compounds
  • Synthetic Organic Chemistry
  • Typical Metal Compounds
  • organotin compound
Mol File:
1461-22-9.mol
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Tributyltin chloride Chemical Properties

Melting point:
-9 °C
Boiling point:
171-173 °C25 mm Hg(lit.)
Density 
1.2 g/mL at 25 °C(lit.)
vapor pressure 
<0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.492(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
0.017g/l
form 
liquid
Specific Gravity
1.186
color 
colorless
Water Solubility 
PRACTICALLY INSOLUBLE
Sensitive 
Moisture Sensitive
BRN 
3535715
Exposure limits
ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)
NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3
Stability:
Hygroscopic
InChIKey
GCTFWCDSFPMHHS-UHFFFAOYSA-M
LogP
2.21 at 23℃
CAS DataBase Reference
1461-22-9(CAS DataBase Reference)
NIST Chemistry Reference
Tri-n-butyltin chloride(1461-22-9)
EPA Substance Registry System
Tributyltin chloride (1461-22-9)
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Safety Information

Hazard Codes 
T,N
Risk Statements 
21-25-36/38-48/23/25-50/53
Safety Statements 
35-36/37/39-45-60-61-26
RIDADR 
UN 2788 6.1/PG 3
WGK Germany 
3
RTECS 
WH6820000
3-9-21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29310095
Hazardous Substances Data
1461-22-9(Hazardous Substances Data)

MSDS

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Tributyltin chloride Usage And Synthesis

Description

Tributyltin chloride is also as Chlorotributyltin, is the chloride of tributyltin. It is a biocide that contaminates foods, especially shellfish. It is an endocrine disrupter in several marine species and is neurotoxic and immuno-toxic in mammals. It has been used as a heat stabilizer, agricultural pesticide and component of antifouling paints2. However, it is perhaps the most acutely toxic chemical to aquatic organisms ever deliberately introduced to water. It has been demonstrated to have an adverse effect on shellfish in France and England, and as a consequence the use of tributyltin‐containing antifouling paints has been restricted in these countries. Other countries have banned the use of tributyltin‐containing antifouling paints or are contemplating restrictions3.

References

  1. Cooke, G. M., et al. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association 42.2(2004):211-220.
  2. Nakatsu, Yusuke, Y. Kotake, and S. Ohta. "Tributyltin-induced cell death is mediated by calpain in PC12 cells."Neurotoxicology 27.4(2006):587-593.
  3. Maguire, R. James. "Environmental aspects of tributyltin." Applied Organometallic Chemistry 1.6(1987):475-498.

Chemical Properties

Colorless or light yellow clear liquid. Soluble in the common organic solvents; including alcohol, heptane, benzene, and toluene; insoluble in cold water, but hydrolyzes in hot water.

Uses

Tributyltin Chloride is a triorganotin compound with insecticidal acitivity. It is an endocrine disruptor as well as an inhibitor for the V-ATPases (potential targets in the treatmen t of diseases such as osteoporosis and cancer). Tributyltin Chloride has the functions of antiseptic, sterilization and mildew proof and widely used in wood preservation, ship paint, etc. Further, it is used in hot end glass coating and rodent-repellent for cable coatings.

Preparation

Tributyltin chloride is prepared by a redistribution reaction by combining stannic chloride and tetrabutyltin:
3 (C4H9)4Sn + SnCl4 → 4 (C4H9)3SnCl.

Definition

ChEBI: Tributyltin chloride is an inorganic molecular entity.

Hazard

A poison by ingestion and skin contact. A severe eye irritant. Tributyl tin compounds are extremely toxic to marine life.

Flammability and Explosibility

Not classified

Toxicology

Tributyltin chloride (TBTCL) is a widely used biocide and heat stabiliser for PVC compositions. TBTCL has been detected in humans and may cause harmful effects on the thyroid, cardiovascular and other organs in humans. It is also an endocrine disruptor with toxic effects on the male reproductive system.TBTCL causes apoptosis and cell cycle arrest. Activation of endoplasmic reticulum stress and inhibition of autophagy are responsible for TBTCL-induced apoptosis and cell cycle arrest. 

Tributyltin chloride Preparation Products And Raw materials

Preparation Products

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