Tributyltin chloride
Tributyltin chloride Basic information
- Product Name:
- Tributyltin chloride
- Synonyms:
-
- TBTC
- N-TRI-TERT-BUTYLTIN CHLORIDE
- CHLOROTRIBUTYLSTANNANE
- CHLOROTRIBUTYLTIN
- CHLOROTRI-N-BUTYLTIN
- tributylchlorostannane
- TRIBUTYLCHLOROTIN
- TRIBUTYLTIN CHLORIDE
- CAS:
- 1461-22-9
- MF:
- C12H27ClSn
- MW:
- 325.51
- EINECS:
- 215-958-7
- Product Categories:
-
- Organometallics
- Alphabetical Listings
- Tin Compound (Environmental Endocrine Disruptors)
- Organometallic Reagents
- Organotin
- Organotin HalidesStable Isotopes
- Alkyl Metals
- Analytical Chemistry
- Classes of Metal Compounds
- Environmental Endocrine Disruptors
- Grignard Reagents & Alkyl Metals
- Sn (Tin) Compounds
- Synthetic Organic Chemistry
- Typical Metal Compounds
- organotin compound
- Mol File:
- 1461-22-9.mol
Tributyltin chloride Chemical Properties
- Melting point:
- -9 °C
- Boiling point:
- 171-173 °C25 mm Hg(lit.)
- Density
- 1.2 g/mL at 25 °C(lit.)
- vapor pressure
- <0.01 mm Hg ( 20 °C)
- refractive index
- n20/D 1.492(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- 0.017g/l
- form
- liquid
- Specific Gravity
- 1.186
- color
- colorless
- Water Solubility
- PRACTICALLY INSOLUBLE
- Sensitive
- Moisture Sensitive
- BRN
- 3535715
- Exposure limits
- ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)
NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3 - Stability:
- Hygroscopic
- InChIKey
- GCTFWCDSFPMHHS-UHFFFAOYSA-M
- LogP
- 2.21 at 23℃
- CAS DataBase Reference
- 1461-22-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Tri-n-butyltin chloride(1461-22-9)
- EPA Substance Registry System
- Tributyltin chloride (1461-22-9)
Safety Information
- Hazard Codes
- T,N
- Risk Statements
- 21-25-36/38-48/23/25-50/53
- Safety Statements
- 35-36/37/39-45-60-61-26
- RIDADR
- UN 2788 6.1/PG 3
- WGK Germany
- 3
- RTECS
- WH6820000
- F
- 3-9-21
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29310095
- Hazardous Substances Data
- 1461-22-9(Hazardous Substances Data)
MSDS
- Language:English Provider:Chlorotributyltin
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
Tributyltin chloride Usage And Synthesis
Description
Tributyltin chloride is also as Chlorotributyltin, is the chloride of tributyltin. It is a biocide that contaminates foods, especially shellfish. It is an endocrine disrupter in several marine species and is neurotoxic and immuno-toxic in mammals. It has been used as a heat stabilizer, agricultural pesticide and component of antifouling paints2. However, it is perhaps the most acutely toxic chemical to aquatic organisms ever deliberately introduced to water. It has been demonstrated to have an adverse effect on shellfish in France and England, and as a consequence the use of tributyltin‐containing antifouling paints has been restricted in these countries. Other countries have banned the use of tributyltin‐containing antifouling paints or are contemplating restrictions3.
References
- Cooke, G. M., et al. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association 42.2(2004):211-220.
- Nakatsu, Yusuke, Y. Kotake, and S. Ohta. "Tributyltin-induced cell death is mediated by calpain in PC12 cells."Neurotoxicology 27.4(2006):587-593.
- Maguire, R. James. "Environmental aspects of tributyltin." Applied Organometallic Chemistry 1.6(1987):475-498.
Chemical Properties
Colorless or light yellow clear liquid. Soluble in the common organic solvents; including alcohol, heptane, benzene, and toluene; insoluble in cold water, but hydrolyzes in hot water.
Uses
Tributyltin Chloride is a triorganotin compound with insecticidal acitivity. It is an endocrine disruptor as well as an inhibitor for the V-ATPases (potential targets in the treatmen t of diseases such as osteoporosis and cancer). Tributyltin Chloride has the functions of antiseptic, sterilization and mildew proof and widely used in wood preservation, ship paint, etc. Further, it is used in hot end glass coating and rodent-repellent for cable coatings.
Preparation
Tributyltin chloride is prepared by a redistribution reaction by combining stannic chloride and tetrabutyltin:
3 (C4H9)4Sn + SnCl4 → 4 (C4H9)3SnCl.
Definition
ChEBI: Tributyltin chloride is an inorganic molecular entity.
Hazard
A poison by ingestion and skin contact. A severe eye irritant. Tributyl tin compounds are extremely toxic to marine life.
Flammability and Explosibility
Not classified
Toxicology
Tributyltin chloride (TBTCL) is a widely used biocide and heat stabiliser for PVC compositions. TBTCL has been detected in humans and may cause harmful effects on the thyroid, cardiovascular and other organs in humans. It is also an endocrine disruptor with toxic effects on the male reproductive system.TBTCL causes apoptosis and cell cycle arrest. Activation of endoplasmic reticulum stress and inhibition of autophagy are responsible for TBTCL-induced apoptosis and cell cycle arrest.
Tributyltin chloride Preparation Products And Raw materials
Preparation Products
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Tributyltin chloride(1461-22-9)Related Product Information
- Choline chloride
- Polyvinyl chloride
- Dibutyltin dilaurate
- Butyltin trichloride
- Tributyltin Hydride
- Tetrabutylphosphonium chloride
- Tributyltetradecylphosphonium chloride
- Fluorotributyltin
- Tin tetrachloride
- STANNOUS CHLORIDE
- Calcium chloride
- Ammonium chloride
- tert-Butyldimethylsilyl chloride
- Thionyl chloride
- TRIMETHYLTIN CHLORIDE
- TRIETHYLTIN CHLORIDE
- Tetrabutyl ammonium chloride
- Potassium chloride