5-Phenoxyisobenzofuran-1(3H)-one Chemical Properties

Boiling point:

422.5±45.0 °C(Predicted)

Density 

1.280

storage temp. 

2-8°C

InChI

InChI=1S/C14H10O3/c15-14-13-7-6-12(8-10(13)9-16-14)17-11-4-2-1-3-5-11/h1-8H,9H2

InChIKey

BTQCNYDOVASZJD-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=C(OC3=CC=CC=C3)C=C2)CO1

5-Phenoxyisobenzofuran-1(3H)-one Usage And Synthesis

Description

5-Phenoxy-l(3H)-isobenzofuranone, with a phenoxy-substituted benzo five-membered ring lactone structure, is a useful intermediate in preparing the derivatives of isoquinoline. The most common method of preparing 5-Phenoxyisobenzofuran-1(3H)-one was utilized, the copper-catalyzed coupling reaction of 5-bromophthalide and phenol in the presence of a base[1].

References

[1] Xi-An Li . “Synthesis of 5-phenoxyisobenzofuran-1(3H)-one as a key intermedate of the drug roxadustat.” Tetrahedron Letters 61 32 (2020): Article 152181.

5-Phenoxyisobenzofuran-1(3H)-one(57830-14-5)Related Product Information

• 4-Aminophthalimide
• Roxadustat
• 5-Aminophthalide
• INDEX NAME NOT YET ASSIGNED
• methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate
• FG-4592 interMediate
• methyl2-(chloromethyl)-4-phenoxybenzoate
• Roxadustat Impurity
• 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester
• methyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate