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Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

Basic information Safety Supplier Related

Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Basic information

Product Name:
Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Synonyms:
  • Roxadustat Impurity 4
  • FG-4592 INT
  • 4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester
  • FG-4592 interMediate
  • 3-Isoquinolinecarboxylic acid, 4-hydroxy-7-phenoxy-, methyl ester
  • FG4592 intermediates
  • ROXA-030
  • 4-Hydroxy-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
CAS:
1455091-10-7
MF:
C17H13NO4
MW:
295.29
Product Categories:
  • Intermediate
  • API
Mol File:
1455091-10-7.mol
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Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Chemical Properties

Boiling point:
534.7±45.0 °C(Predicted)
Density 
1.320±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
5.80±0.50(Predicted)
InChI
InChI=1S/C17H13NO4/c1-21-17(20)15-16(19)14-8-7-13(9-11(14)10-18-15)22-12-5-3-2-4-6-12/h2-10,19H,1H3
InChIKey
YTWDBRIDKWWANA-UHFFFAOYSA-N
SMILES
C1C2=C(C=CC(OC3=CC=CC=C3)=C2)C(O)=C(C(OC)=O)N=1
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Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Usage And Synthesis

Uses

Methyl 4-Hydroxy-7-phenoxyisoquinoline-3-carboxylate is an intermediate of N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine (H948180), a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.

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