6,8-Diprenylorobol Chemical Properties

Boiling point:

667.1±55.0 °C(Predicted)

Density 

1.301±0.06 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder

pka

7.00±0.20(Predicted)

color 

Yellow

6,8-Diprenylorobol Usage And Synthesis

Uses

6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS[1][2].

target

Estrogen receptor | Antifection | HIV | Progestogen receptor

References

[1] Choi YJ, et, al. 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. Environ Toxicol. 2021 May;36(5):914-925. DOI:10.1002/tox.23093
[2] Tuan Anh HL, et, al. Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation. J Asian Nat Prod Res. 2017 May;19(5):510-518. DOI:10.1080/10286020.2016.1232253

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