beta-Estradiol-3-sulfate-17-glucopyranosiduronic acid dipotassium salt
beta-Estradiol-3-sulfate-17-glucopyranosiduronic acid dipotassium salt Basic information
- Product Name:
- beta-Estradiol-3-sulfate-17-glucopyranosiduronic acid dipotassium salt
- Synonyms:
-
- 1,3,5(10)-ESTRATRIENE-3,17BETA-DIOL 17-PENTANOATE
- 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 17-VALERATE
- 1,3,5(10)-ESTRATRIEN-3,17B-DIOL-17-VALERATE
- 1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL 17-VALERATE
- 17B-ESTRADIOL-17-VALERATE
- 17B-ESTRADIOL VALERATE
- 17BETA-ESTRADIOL VALERATE
- 17-BETA-ESTRADIOL 17-VALERATE
- CAS:
- 10392-35-5
- MF:
- C24H33KO11S
- MW:
- 568.68
- EINECS:
- 213-559-2
- Product Categories:
-
- Glucuronides
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- Mol File:
- 10392-35-5.mol
beta-Estradiol-3-sulfate-17-glucopyranosiduronic acid dipotassium salt Chemical Properties
- Melting point:
- >223°C (dec.)
- storage temp.
- −20°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Safety Information
- Hazard Codes
- T,Xn
- Risk Statements
- 60-61-40-20/21/22
- Safety Statements
- 53-45-36-22
- WGK Germany
- 3
- RTECS
- KG5793000
MSDS
- Language:English Provider:SigmaAldrich
beta-Estradiol-3-sulfate-17-glucopyranosiduronic acid dipotassium salt Usage And Synthesis
Description
Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol , and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma. Sulfated estrogens, including estradiol 3-sulfate, can be converted back to the parent compound by sulfatases. Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most commonly leading to excretion in urine and bile.
Chemical Properties
White to Off-White Solid
Uses
A 17β-Estradiol (E888000) metabolite.
References
[1] R RAFTOGIANIS. Estrogen metabolism by conjugation.[J]. Journal of the National Cancer Institute. Monographs, 2000, 27: 113-124. DOI: 10.1093/oxfordjournals.jncimonographs.a024234
[2] D W LOE. ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.[J]. The Journal of Biological Chemistry, 1996, 271 16: 9683-9689. DOI: 10.1074/jbc.271.16.9683
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beta-Estradiol-3-sulfate-17-glucopyranosiduronic acid dipotassium salt(10392-35-5)Related Product Information
- Dimethyl sulfate
- Barium sulfate
- 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL
- Dextran
- Sodium sulfate
- Ammonium sulfate
- Magnesium sulfate heptahydrate
- Estradiol
- POTASSIUM PHOSPHITE
- Alkyl polyglucoside
- Ethynyl estradiol
- sulfate
- β-Estradiol
- Estradiol valerate
- GOLD COAST SOLUTION NO 1
- beta-Estradiol-3-sulfate-17-glucopyranosiduronic acid dipotassium salt