Glycerol phenylbutyrate
Glycerol phenylbutyrate Basic information
- Product Name:
- Glycerol phenylbutyrate
- Synonyms:
-
- Glycerol phenylbutryate
- Ravicti
- Glycerol phenylbutyrate
- glyceryl tri-(4-phenylbutyrate)
- BENZENEBUTANOIC ACID, 1,2,3-PROPANETRIYL ESTER
- Propane-1,2,3-triyl tris(4-phenylbutanoate)
- HPN-100
- Benzenebutanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester
- CAS:
- 611168-24-2
- MF:
- C33H38O6
- MW:
- 530.65
- Product Categories:
-
- APIS
- Mol File:
- 611168-24-2.mol
Glycerol phenylbutyrate Chemical Properties
- Boiling point:
- 621.2±45.0 °C(Predicted)
- Density
- 1.131±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:150.0(Max Conc. mg/mL);282.67(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);94.22(Max Conc. mM) - form
- Oil
- color
- Colourless
- InChIKey
- ZSDBFLMJVAGKOU-UHFFFAOYSA-N
- SMILES
- C(OC(=O)CCCC1=CC=CC=C1)C(OC(=O)CCCC1=CC=CC=C1)COC(=O)CCCC1=CC=CC=C1
Glycerol phenylbutyrate Usage And Synthesis
Uses
Tri(4-phenylbutyryl)glycerol is a drug that is currently under development for treatment of urea cyclic disorders (UCDs). It works by preventing the harmful buildup of ammonia in the body.
Definition
ChEBI: Glycerol phenylbutyrate is a triglyceride.
Biological Activity
Glycerol phenylbutyrate, a triacylglycerol, is a prodrug of ER stress inhibitor 4-phenylbutyric acid (PBA). Glycerol phenylbutyrate is a nitrogen-binding agent approved for the chronic management of adult and pediatric patients (≥2 years of age) with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone.
in vivo
Glycerol phenylbutyrate (GPB) has the potential for the treatment of hyperammonemia. Glycerol phenylbutyrate (GPB) may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders[1][2].
IC 50
Sigma 2 Receptor
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