Bis-PEG4-acid Chemical Properties

Boiling point:

445.4±40.0 °C(Predicted)

Density 

1.239±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Soluble in Water, DMSO, DMF

pka

3.97±0.10(Predicted)

form 

Solid-Liquid Mixture

color 

Colorless to light yellow

Bis-PEG4-acid Usage And Synthesis

Description

Bis-PEG3-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298. DOI:10.1021/acs.jmedchem.9b01264

Bis-PEG4-acid(96517-92-9)Related Product Information

• Bis-Propargyl-PEG4
• HO-PEG8-CH2CH2COOH
• Maleimide-PEG2-NHS Ester
• PEG5-acid
• HOOC-PEG7-CH2CH2COOH
• alpha, oMega-Dipropionic acid triethylene glycol
• α,ω-dipropionic acid tetraethylene glycol
• Bis-PEG2-acid
• Bis-PEG6-acid
• α,ω,-dipropionic acid nonaethylene glycol
• alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl)
• Bis-PEG4-t-butyl ester
• Bis-PEG10-acid
• alpha, oMega-Dipropionic acid hexaethylene glycol
• Bis-PEG6-t-butyl ester
• Bis-PEG1-NHS ester
• Bis-PEG5-t-butyl ester
• Bis-PEG9-t-butyl ester