HOOC-PEG7-CH2CH2COOH
HOOC-PEG7-CH2CH2COOH Basic information
- Product Name:
- HOOC-PEG7-CH2CH2COOH
- Synonyms:
-
- HOOC-PEG7-CH2CH2COOH
- HOOCCH2CH2O-PEG7-CH2CH2COOH
- 4,7,10,13,16,19,22,25-Octaoxaoctacosanedioic acid
- Bis-PEG8-COOH
- 4,7,10,13,16,19,22,25-Octaoxaoctacosane-1,28-dioic Acid
- Di-Acid-PEG8
- HOOCCH2CH2O-PEG7-CH2CH2COOH/4,7,10,13,16,19,22,25-Octaoxaoctacosanedioic acid
- Bis-PEG8-acid BIS-
- CAS:
- 1246189-43-4
- MF:
- C20H38O12
- MW:
- 470.51
- Product Categories:
-
- peg
- Mol File:
- 1246189-43-4.mol
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HOOC-PEG7-CH2CH2COOH Chemical Properties
- Boiling point:
- 601.8±55.0 °C(Predicted)
- Density
- 1.179±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.97±0.10(Predicted)
- form
- Solid
- color
- White to off-white
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HOOC-PEG7-CH2CH2COOH Usage And Synthesis
Description
Bis-PEG8-acid is a PEG linker containing terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50
PEGs; Cleavable Linker
References
[1] Gregory Slobodkin, et al. Polyamine derivatives. WO2010108108A2
HOOC-PEG7-CH2CH2COOHSupplier
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