LOXO-195
LOXO-195 Basic information
- Product Name:
- LOXO-195
- Synonyms:
-
- LOXO-195
- (18bR)-17-Fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-10H-5,7-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-10-one
- Selitrectinib Racemate
- (6RS)-LOXO-195
- Selitrectinib(LOXO-195) Racemate
- 12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR)-
- LOXO195 R racemic
- LOXO-195(3aR)
- CAS:
- 1350884-56-8
- MF:
- C20H21FN6O
- MW:
- 380.42
- Mol File:
- 1350884-56-8.mol
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LOXO-195 Chemical Properties
- Density
- 1.51±0.1 g/cm3(Predicted)
- pka
- 11.44±0.40(Predicted)
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LOXO-195 Usage And Synthesis
Description
LOXO-195 is an orally available, highly potent, and selective TRK kinase inhibitor designed to overcome drug resistance mediated by acquired mutations. Although responses to TRK inhibition can be dramatic and durable; however, eventually emergence of acquired resistance is found to be inevitable.
LOXO-195Supplier
Shanghai Changyu Medical Technology Co. Ltd. Gold
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Shanghai Changyan Chem & Tech Co., Ltd.
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Shanghai Rechem science Co., Ltd.
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