SPDP-dPEG(R)12-NHS ester Chemical Properties

storage temp. 

-20°C

solubility 

water: soluble

form 

solid or viscous liquid

Water Solubility 

water: soluble

SMILES

O=C(CCSSC1=CC=CC=N1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

SPDP-dPEG(R)12-NHS ester Usage And Synthesis

Uses

SPDP-type reagents have an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a suflhydryl-reactive 2-pyridyldithio group at the opposite end. PEG12-SPDP has a 12-unit polyethylene glycol spacer arm, which confers greater solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using an SPDP reagent

reaction suitability

reagent type: cross-linking reagent

SPDP-dPEG(R)12-NHS ester(924280-65-9)Related Product Information

• SPDP-PEG8-acid
• SPDP-PEG4-acid
• SPDP-PEG4-NHS ester
• SPDP-PEG8-NHS ester