11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties

Melting point:

235-238°C

Boiling point:

591.5±50.0 °C(Predicted)

Density 

1.38±0.1 g/cm3(Predicted)

vapor pressure 

0Pa at 25℃

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

11.93±0.70(Predicted)

color 

White to Light Yellow

Water Solubility 

815mg/L at 20℃

LogP

0.8 at 25℃

CAS DataBase Reference

13951-70-7(CAS DataBase Reference)

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Usage And Synthesis

Related substances

Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.

Chemical Properties

White Crystalline Solid

Uses

A metabolite of Budesonide (B689490), an antiinflammatory agent.

Uses

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione(13951-70-7)Related Product Information

• Budesonide Sulfate SodiuM (Mixture of DiastereoMers)
• 14,15-Dehydro Budesonide
• 9α-BroMobudesonide
• 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers)
• Desonide
• Budesonide
• Di-Norbudesonide (Mixture of DiastereoMers)
• 9,11-Anhydrobudesonide
• Budesonide EP Impurity D (Mixture of Diastereomers)
• 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
• (16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione
• 1,2-Dehydrobudesonide
• Budesonide Impurity 1 (Mixture of Diastereomers)
• Budesonide EP Impurity A-d4
• Flunisolide
• (r)-budesonide
• 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
• Ciclesonide