Adrenal corticosteroids
Adrenal corticosteroid is the general term for adrenal cortex hormones, belonging to steroid compounds. It can be divided into three categories:
(1) mineralocorticoid hormone secreted by Zona glomerulosa, including aldosterone and deoxycorticosterone and so on.
(2) glucocorticoid, it is synthesized and secreted from the zona fasciculata, including hydrocortisone and cortisone, etc., its secretion and production are regulated by the adrenocorticotropic hormone (ACTH).
(3) sex hormones, secreted by the zona reticularis, usually referred to adrenocortical hormones, excluding such kind of sex hormones.
Commonly used clinical adrenocortical hormones mainly refer to glucocorticoids. Under physiological conditions, the secretion of glucocorticoids mainly affects the metabolism of substances. Glucocorticoids beyond physiological dose have anti-inflammatory, anti-immune and other pharmacological effects.
ACTH is a kind of important hormones that maintain the normal adrenal gland and function. Its synthesis and secretion proceed inside the pituitary basophilic cells when the anterior pituitary is under the action of hypothalamus corticotropin-releasing hormone (CRH). Glucocorticoids play a long negative feedback effect on hypothalamus and anterior pituitary, inhibiting the secretion of CRH and ACTH. In physiological conditions, the hypothalamus, pituitary and adrenal gland are maintained in a relative dynamic balance with ACTH deficiency being able to cause adrenal cortical atrophy and its reduced secretion capability. The ACTH also has a short negative feedback regulation that controls its own release.
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- Structure:
- Chemical Name:
- Fluticasone propionate
- CAS:
- 80474-14-2
- MF:
- C25H31F3O5S
- Structure:
- Chemical Name:
- Dexamethasone
- CAS:
- 50-02-2
- MF:
- C22H29FO5
- Structure:
- Chemical Name:
- Fluocinolone Acetonide
- CAS:
- 67-73-2
- MF:
- C24H30F2O6
- Structure:
- Chemical Name:
- 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- CAS:
- 13951-70-7
- MF:
- C21H28O6
- Structure:
- Chemical Name:
- Hydrocortisone
- CAS:
- 50-23-7
- MF:
- C21H30O5
- Chemical Name:
- Ciclesonide
- CAS:
- 141845-82-1
- MF:
- C32H45O7
- Structure:
- Chemical Name:
- Dexamethasone-17-acetate
- CAS:
- 1177-87-3
- MF:
- C24H31FO6
- Structure:
- Chemical Name:
- Deflazacort
- CAS:
- 14484-47-0
- MF:
- C25H31NO6
- Structure:
- Chemical Name:
- Betamethasone
- CAS:
- 378-44-9
- MF:
- C22H29FO5
- Structure:
- Chemical Name:
- Prednisone
- CAS:
- 53-03-2
- MF:
- C21H26O5
- Structure:
- Chemical Name:
- Hydrocortisone acetate
- CAS:
- 50-03-3
- MF:
- C23H32O6
- Structure:
- Chemical Name:
- Betamethasone 17,21-dipropionate
- CAS:
- 5593-20-4
- MF:
- C28H37FO7
- Structure:
- Chemical Name:
- Triamcinolone acetonide
- CAS:
- 76-25-5
- MF:
- C24H31FO6
- Structure:
- Chemical Name:
- Budesonide
- CAS:
- 51333-22-3
- MF:
- C25H34O6
- Structure:
- Chemical Name:
- dl-threo-Ritalinic Acid Isopropyl Ester
- CAS:
- 93148-46-0
- MF:
- C16H23NO2
- Chemical Name:
- glucocorticoid hormone
- Structure:
- Chemical Name:
- DEFLAZACORT
- CAS:
- 13649-88-2
- MF:
- C23H29NO4
- Structure:
- Chemical Name:
- Hydrocortisone
- CAS:
- 74050-20-7
- MF:
- C26H36O7
- Structure:
- Chemical Name:
- Dexamethasone 21-phosphate disodium salt
- CAS:
- 2392-39-4
- MF:
- C22H28FNa2O8P
- Structure:
- Chemical Name:
- Diflorasone
- CAS:
- 2557-49-5
- MF:
- C22H28F2O5
- Structure:
- Chemical Name:
- Hydrocortisone sodium succinate
- CAS:
- 125-04-2
- MF:
- C25H33O8.Na
- Structure:
- Chemical Name:
- Mometasone furoate
- CAS:
- 83919-23-7
- MF:
- C27H30Cl2O6
- Structure:
- Chemical Name:
- Hydrocortisone-17-butyrate
- CAS:
- 13609-67-1
- MF:
- C25H36O6
- Structure:
- Chemical Name:
- Betamethasone 17-valerate
- CAS:
- 2152-44-5
- MF:
- C27H37FO6
- Structure:
- Chemical Name:
- Betamethasone 21-acetate
- CAS:
- 987-24-6
- MF:
- C24H31FO6
- Structure:
- Chemical Name:
- Triamcinolone
- CAS:
- 124-94-7
- MF:
- C21H27FO6
- Structure:
- Chemical Name:
- Hydrocortisone hemisuccinate hydrate
- CAS:
- 83784-20-7
- MF:
- C25H36O9
- Structure:
- Chemical Name:
- Dexamethasone sodium phosphate
- CAS:
- 55203-24-2
- MF:
- C22H28FNa2O8P
- Structure:
- Chemical Name:
- Methylprednisolone
- CAS:
- 83-43-2
- MF:
- C22H30O5
- Structure:
- Chemical Name:
- Deoxycorticosterone acetate
- CAS:
- 56-47-3
- MF:
- C23H32O4
- Chemical Name:
- Bevacizumab
- CAS:
- 216974-75-3
- MF:
- C6638H10160N1720O2108S44
- Structure:
- Chemical Name:
- Prednisolone
- CAS:
- 50-24-8
- MF:
- C21H28O5
- Structure:
- Chemical Name:
- Fluocinonide
- CAS:
- 356-12-7
- MF:
- C26H32F2O7
- Structure:
- Chemical Name:
- Desoxycorticosterone
- CAS:
- 64-85-7
- MF:
- C21H30O3
- Structure:
- Chemical Name:
- Beclomethasone dipropionate
- CAS:
- 5534-09-8
- MF:
- C28H37ClO7
- Structure:
- Chemical Name:
- Hydrocortisone 21-hemisuccinate
- CAS:
- 2203-97-6
- MF:
- C25H34O8
- Structure:
- Chemical Name:
- Betamethasone 21-phosphate disodium
- CAS:
- 151-73-5
- MF:
- C22H28FNa2O8P
- Structure:
- Chemical Name:
- Fluticasone
- CAS:
- 90566-53-3
- MF:
- C22H27F3O4S
- Structure:
- Chemical Name:
- Prednisone 21-acetate
- CAS:
- 125-10-0
- MF:
- C23H28O6
- Structure:
- Chemical Name:
- Fludrocortisone acetate
- CAS:
- 514-36-3
- MF:
- C23H31FO6
- Structure:
- Chemical Name:
- Meprednisone
- CAS:
- 1247-42-3
- MF:
- C22H28O5
- Structure:
- Chemical Name:
- (r)-budesonide
- CAS:
- 51372-29-3
- MF:
- C25H34O6
- Structure:
- Chemical Name:
- Clobetasol propionate
- CAS:
- 25122-46-7
- MF:
- C25H32ClFO5
- Structure:
- Chemical Name:
- Methylprednisolone acetate
- CAS:
- 53-36-1
- MF:
- C24H32O6
- Structure:
- Chemical Name:
- CORTISONE
- CAS:
- 53-06-5
- MF:
- C21H28O5
- Structure:
- Chemical Name:
- Isoflupredone
- CAS:
- 338-95-4
- MF:
- C21H27FO5
- Structure:
- Chemical Name:
- Prednisolone phosphate sodium
- CAS:
- 125-02-0
- MF:
- C21H27Na2O8P
- Structure:
- Chemical Name:
- Halometasone
- CAS:
- 50629-82-8
- MF:
- C22H27ClF2O5
- Structure:
- Chemical Name:
- BECLOMETHASONE
- CAS:
- 4419-39-0
- MF:
- C22H29ClO5
- Structure:
- Chemical Name:
- Flurandrenolide
- CAS:
- 1524-88-5
- MF:
- C24H33FO6
- Structure:
- Chemical Name:
- Halcinonide
- CAS:
- 3093-35-4
- MF:
- C24H32ClFO5
- Structure:
- Chemical Name:
- Prednisolone-21-acetate
- CAS:
- 52-21-1
- MF:
- C23H30O6
- Structure:
- Chemical Name:
- Cortisone acetate
- CAS:
- 50-04-4
- MF:
- C23H30O6
- Structure:
- Chemical Name:
- Fluorometholone
- CAS:
- 426-13-1
- MF:
- C22H29FO4
- Structure:
- Chemical Name:
- Prednisolone sodium succinate
- CAS:
- 1715-33-9
- MF:
- C25H31O8.Na
- Structure:
- Chemical Name:
- Mometasone
- CAS:
- 105102-22-5
- MF:
- C22H28Cl2O4
- Structure:
- Chemical Name:
- DEXAMETHASONE SODIUM PHOSPHATE
- CAS:
- 312-93-6
- MF:
- C22H30FO8P
- Structure:
- Chemical Name:
- Triamcinolone acetonide 21-acetate
- CAS:
- 3870-07-3
- MF:
- C26H33FO7
- Structure:
- Chemical Name:
- Hydrocortisone sodium phosphate
- CAS:
- 6000-74-4
- MF:
- C21H29O8P.2Na
- Structure:
- Chemical Name:
- Fluocortolone
- CAS:
- 152-97-6
- MF:
- C22H29FO4
- Chemical Name:
- Methylprednisolone Hemisuccinate
- Structure:
- Chemical Name:
- Fludrocortisone
- CAS:
- 127-31-1
- MF:
- C21H29FO5
- Structure:
- Chemical Name:
- cloprednol
- CAS:
- 5251-34-3
- MF:
- C21H25ClO5
- Structure:
- Chemical Name:
- Clobetasol
- CAS:
- 25122-41-2
- MF:
- C22H28ClFO4
- Chemical Name:
- DexamethasoneAcefurate
- Structure:
- Chemical Name:
- DEXAMETHASONE ACETATE, MONOHYDRATE
- CAS:
- 55812-90-3
- MF:
- C24H31FO6.H2O