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Adrenal corticosteroids

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Adrenal corticosteroid is the general term for adrenal cortex hormones, belonging to steroid compounds. It can be divided into three categories:
(1)  mineralocorticoid hormone secreted by Zona glomerulosa, including aldosterone and deoxycorticosterone and so on.
(2)  glucocorticoid, it is synthesized and secreted from the zona fasciculata, including hydrocortisone and cortisone, etc., its secretion and production are regulated by the adrenocorticotropic hormone (ACTH).
(3)  sex hormones, secreted by the zona reticularis, usually referred to adrenocortical hormones, excluding such kind of sex hormones.
Commonly used clinical adrenocortical hormones mainly refer to glucocorticoids. Under physiological conditions, the secretion of glucocorticoids mainly affects the metabolism of substances. Glucocorticoids beyond physiological dose have anti-inflammatory, anti-immune and other pharmacological effects.

ACTH is a kind of important hormones that maintain the normal adrenal gland and function. Its synthesis and secretion proceed inside the pituitary basophilic cells when the anterior pituitary is under the action of hypothalamus corticotropin-releasing hormone (CRH). Glucocorticoids play a long negative feedback effect on hypothalamus and anterior pituitary, inhibiting the secretion of CRH and ACTH. In physiological conditions, the hypothalamus, pituitary and adrenal gland are maintained in a relative dynamic balance with ACTH deficiency being able to cause adrenal cortical atrophy and its reduced secretion capability. The ACTH also has a short negative feedback regulation that controls its own release.

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Structure:
Chemical Name:
Fluticasone propionate
CAS:
80474-14-2
MF:
C25H31F3O5S
Structure:
Chemical Name:
Dexamethasone
CAS:
50-02-2
MF:
C22H29FO5
Structure:
Chemical Name:
fluocinolone16,17-acetonide
CAS:
67-73-2
MF:
C24H30F2O6
Structure:
Chemical Name:
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
CAS:
13951-70-7
MF:
C21H28O6
Structure:
Chemical Name:
Hydrocortisone
CAS:
50-23-7
MF:
C21H30O5
Chemical Name:
Ciclesonide
CAS:
141845-82-1
MF:
C32H45O7
Structure:
Chemical Name:
Dexamethasone-17-acetate
CAS:
1177-87-3
MF:
C24H31FO6
Structure:
Chemical Name:
Deflazacort
CAS:
14484-47-0
MF:
C25H31NO6
Structure:
Chemical Name:
Betamethasone
CAS:
378-44-9
MF:
C22H29FO5
Structure:
Chemical Name:
Prednisone
CAS:
53-03-2
MF:
C21H26O5
Structure:
Chemical Name:
Hydrocortisone acetate
CAS:
50-03-3
MF:
C23H32O6
Structure:
Chemical Name:
Betamethasone 17,21-dipropionate
CAS:
5593-20-4
MF:
C28H37FO7
Structure:
Chemical Name:
Triamcinolone acetonide
CAS:
76-25-5
MF:
C24H31FO6
Structure:
Chemical Name:
Budesonide
CAS:
51333-22-3
MF:
C25H34O6
Structure:
Chemical Name:
dl-threo-Ritalinic Acid Isopropyl Ester
CAS:
93148-46-0
MF:
C16H23NO2
Chemical Name:
glucocorticoid hormone
Structure:
Chemical Name:
DEFLAZACORT
CAS:
13649-88-2
MF:
C23H29NO4
Structure:
Chemical Name:
Hydrocortisone
CAS:
74050-20-7
MF:
C26H36O7
Structure:
Chemical Name:
Dexamethasone 21-phosphate disodium salt
CAS:
2392-39-4
MF:
C22H28FNa2O8P
Structure:
Chemical Name:
Diflorasone
CAS:
2557-49-5
MF:
C22H28F2O5
Structure:
Chemical Name:
Hydrocortisone sodium succinate
CAS:
125-04-2
MF:
C25H33O8.Na
Structure:
Chemical Name:
Mometasone furoate
CAS:
83919-23-7
MF:
C27H30Cl2O6
Structure:
Chemical Name:
Hydrocortisone-17-butyrate
CAS:
13609-67-1
MF:
C25H36O6
Structure:
Chemical Name:
Betamethasone 17-valerate
CAS:
2152-44-5
MF:
C27H37FO6
Structure:
Chemical Name:
Betamethasone 21-acetate
CAS:
987-24-6
MF:
C24H31FO6
Structure:
Chemical Name:
Triamcinolone
CAS:
124-94-7
MF:
C21H27FO6
Structure:
Chemical Name:
Hydrocortisone hemisuccinate hydrate
CAS:
83784-20-7
MF:
C25H36O9
Structure:
Chemical Name:
Dexamethasone sodium phosphate
CAS:
55203-24-2
MF:
C22H28FNa2O8P
Structure:
Chemical Name:
Methylprednisolone
CAS:
83-43-2
MF:
C22H30O5
Structure:
Chemical Name:
Deoxycorticosterone acetate
CAS:
56-47-3
MF:
C23H32O4
Chemical Name:
Bevacizumab
CAS:
216974-75-3
MF:
C6638H10160N1720O2108S44
Structure:
Chemical Name:
Prednisolone
CAS:
50-24-8
MF:
C21H28O5
Structure:
Chemical Name:
Fluocinonide
CAS:
356-12-7
MF:
C26H32F2O7
Structure:
Chemical Name:
Desoxycorticosterone
CAS:
64-85-7
MF:
C21H30O3
Structure:
Chemical Name:
Beclomethasone dipropionate
CAS:
5534-09-8
MF:
C28H37ClO7
Structure:
Chemical Name:
Hydrocortisone 21-hemisuccinate
CAS:
2203-97-6
MF:
C25H34O8
Structure:
Chemical Name:
Betamethasone 21-phosphate disodium
CAS:
151-73-5
MF:
C22H28FNa2O8P
Structure:
Chemical Name:
Fluticasone
CAS:
90566-53-3
MF:
C22H27F3O4S
Structure:
Chemical Name:
Prednisone 21-acetate
CAS:
125-10-0
MF:
C23H28O6
Structure:
Chemical Name:
Fludrocortisone acetate
CAS:
514-36-3
MF:
C23H31FO6
Structure:
Chemical Name:
Meprednisone
CAS:
1247-42-3
MF:
C22H28O5
Structure:
Chemical Name:
(r)-budesonide
CAS:
51372-29-3
MF:
C25H34O6
Structure:
Chemical Name:
Clobetasol propionate
CAS:
25122-46-7
MF:
C25H32ClFO5
Structure:
Chemical Name:
Methylprednisolone acetate
CAS:
53-36-1
MF:
C24H32O6
Structure:
Chemical Name:
CORTISONE
CAS:
53-06-5
MF:
C21H28O5
Structure:
Chemical Name:
Isoflupredone
CAS:
338-95-4
MF:
C21H27FO5
Structure:
Chemical Name:
Prednisolone phosphate sodium
CAS:
125-02-0
MF:
C21H27Na2O8P
Structure:
Chemical Name:
Halometasone
CAS:
50629-82-8
MF:
C22H27ClF2O5
Structure:
Chemical Name:
BECLOMETHASONE
CAS:
4419-39-0
MF:
C22H29ClO5
Structure:
Chemical Name:
Flurandrenolide
CAS:
1524-88-5
MF:
C24H33FO6
Structure:
Chemical Name:
Halcinonide
CAS:
3093-35-4
MF:
C24H32ClFO5
Structure:
Chemical Name:
Prednisolone-21-acetate
CAS:
52-21-1
MF:
C23H30O6
Structure:
Chemical Name:
Cortisone acetate
CAS:
50-04-4
MF:
C23H30O6
Structure:
Chemical Name:
Fluorometholone
CAS:
426-13-1
MF:
C22H29FO4
Structure:
Chemical Name:
Prednisolone sodium succinate
CAS:
1715-33-9
MF:
C25H31O8.Na
Structure:
Chemical Name:
Mometasone
CAS:
105102-22-5
MF:
C22H28Cl2O4
Structure:
Chemical Name:
DEXAMETHASONE SODIUM PHOSPHATE
CAS:
312-93-6
MF:
C22H30FO8P
Structure:
Chemical Name:
Triamcinolone acetonide 21-acetate
CAS:
3870-07-3
MF:
C26H33FO7
Structure:
Chemical Name:
Hydrocortisone sodium phosphate
CAS:
6000-74-4
MF:
C21H29O8P.2Na
Structure:
Chemical Name:
Fluocortolone
CAS:
152-97-6
MF:
C22H29FO4
Chemical Name:
Methylprednisolone Hemisuccinate
Structure:
Chemical Name:
Fludrocortisone
CAS:
127-31-1
MF:
C21H29FO5
Structure:
Chemical Name:
cloprednol
CAS:
5251-34-3
MF:
C21H25ClO5
Structure:
Chemical Name:
Clobetasol
CAS:
25122-41-2
MF:
C22H28ClFO4
Chemical Name:
DexamethasoneAcefurate
Structure:
Chemical Name:
DEXAMETHASONE ACETATE, MONOHYDRATE
CAS:
55812-90-3
MF:
C24H31FO6.H2O