Mometasone Chemical Properties

Melting point:

>211oC (dec.)

Boiling point:

586.6±50.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

pka

12.08±0.70(Predicted)

form 

Solid

color 

White to Pale Beige

InChIKey

WOFMFGQZHJDGCX-MCUOXHNDNA-N

SMILES

[C@]1(OC(=O)C2OC=CC=2)([C@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C)C(CCl)=O |&1:0,9,12,14,24,26,28,31,r|

CAS DataBase Reference

105102-22-5(CAS DataBase Reference)

Mometasone Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

Mometasone (Mometasone EP Impurity G) is a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders. It can be applied to the skin, inhaled, or used in the nose. It is used to alleviate inflammation and itchiness in skin conditions that respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis. Mometasone furoate, not mometasone, is used in medical products.

Definition

ChEBI: Mometasone is an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a chlorinated steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug, a dermatologic drug, a vasoconstrictor agent and an anti-allergic agent. It is functionally related to a Delta(1)-progesterone.

Side effects

The most common side effects are an unpleasant smell and a dry or sore nose or throat.

in vivo

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