Basic information Safety Supplier Related

8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID

Basic information Safety Supplier Related

8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID Basic information

Product Name:
8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID
Synonyms:
  • 8[R]-HETE
  • 8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID
  • 8(R)-hydroxy-(5Z,9E,11Z,14Z)-*eicosatetraenoic ac
  • NLUNAYAEIJYXRB-GTYUHVKWSA-N
  • 5,9,11,14-Eicosatetraenoic acid, 8-hydroxy-, (5Z,8R,9E,11Z,14Z)-
  • 8(R)-hydroxy-5(Z),9(E),11(Z),14(Z)-ETA
CAS:
105500-09-2
MF:
C20H32O3
MW:
320.47
EINECS:
200-578-6
Mol File:
105500-09-2.mol
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8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID Chemical Properties

Boiling point:
471.1±45.0 °C(Predicted)
Density 
0.984±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
pka
4.75±0.10(Predicted)
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Safety Information

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38
Safety Statements 
16-26-36-7
RIDADR 
UN 1170 3/PG 2
WGK Germany 
3

MSDS

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8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID Usage And Synthesis

Uses

8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.

Definition

ChEBI: A HETE having an (8R)-hydroxy group and (5Z)-, (9E)-, (11Z)- and (14Z)-double bonds.

References

[1] Meijer, et al. Stereospecific induction of starfish oocyte maturation by (8R)-hydroxyeicosatetraenoic acid. J. Biol. Chem. 261(36), 17040-17047 (1986).

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