(HYDROXYMETHYL)-2-PYRROLIDINONE Chemical Properties

Melting point:

77-79.5 °C

Boiling point:

185-188 °C(Press: 4 Torr)

Density 

1.213±0.06 g/cm3(Predicted)

pka

13.41±0.10(Predicted)

CAS DataBase Reference

15438-71-8(CAS DataBase Reference)

EPA Substance Registry System

2-Pyrrolidinone, 1-(hydroxymethyl)- (15438-71-8)

Safety Information

TSCA 

TSCA listed

(HYDROXYMETHYL)-2-PYRROLIDINONE Usage And Synthesis

Uses

1-(hydroxymethyl)pyrrolidone-2-one can be used as a pharmaceutical synthesis intermediate. If 1-(hydroxymethyl)pyrrolidone-2-one is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and thoroughly wash the skin with soap and water. If discomfort persists, seek medical attention.

Synthesis

1-(Hydroxymethyl)pyrrolidin-2-one was prepared as follows: 2-pyrrolidinone (212.4 g, 2.0 mol) and potassium hydroxide (0.6 g) were heated to 80 C and oligoformaldehyde (75.6 g, 2.6 mol) was added within 10 min and the mixture was kept at 75 C - 80 C for 1/2 hour. The desired product was then crystallized from 1 part benzene to give 227 g of 1-(hydroxymethyl)pyrrolidin-2-one (88.2%) with a melting point product at 78°-80°C.

(HYDROXYMETHYL)-2-PYRROLIDINONE(15438-71-8)Related Product Information

• Z-D-PYR-OH
• Z-PYR-OH
• BOC-PYR-OH
• (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER
• Streptolydigin
• (S)-(+)-5-HYDROXYMETHYL-2-PYRROLIDINONE 97%,(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE
• (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate
• (R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,5-(Hydroxymethyl)-2-pyrrolidinone
• Z-PYR-OSU
• Z-PGLU-PRO-OBZL
• BOC-PYR-OH DCHA
• 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE
• (+)-(3R,7aS)-Tetrahydro-3-phenyl-3H,5H-pyrrolo1,2-coxaole-5-one
• (4R)-BOC-4-BENZYL-PYR-OH
• Z-PYR-ONP
• (HYDROXYMETHYL)-2-PYRROLIDINONE
• N-hydroxymethylsuccinimide
• Z-PGLU-HIS-OH