4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Chemical Properties

Melting point:

65-69 °C(lit.)

Boiling point:

145-152/5mm

Density 

1.376

Flash point:

177℃

storage temp. 

2-8°C

form 

powder to crystal

color 

White to Yellow to Green

Water Solubility 

8.999mg/L(37 ºC)

CAS DataBase Reference

62433-26-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2914500090

MSDS

• Language:English Provider:SigmaAldrich

4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Usage And Synthesis

Uses

4''-Chloro-5-fluoro-2-hydroxybenzophenone is a metabolite of Progabide (P755350) which is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity. 4''-Chloro-5-fluoro-2-hydroxybenzophenone is also used as a reagent in the synthesis of a series of novel dihydrobenzofuranols which displayed antibacterial activity comparable to bacitracin, ciprofloxacin and gentamicin.

Preparation

Preparation by Fries rearrangement of p-fluorophenyl p-chlorobenzoate,
? with titanium tetrachloride at 150° for 18 h (81%);
? with aluminium chloride, at 130° for 2 h (98%) or at 200° for 5 min or for 15 min (65%).

4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE(62433-26-5)Related Product Information

• 2'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
• 5-Fluorosalicylaldehyde
• 4-Fluorophenol
• 4-Fluoro-2-methylphenol
• 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
• 3'-Fluoroacetophenone
• 3-FLUOROBENZOPHENONE
• 4-CHLORO-3'-FLUOROBENZOPHENONE
• 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
• 4-Chlorobenzophenone
• 2-ETHYL-4-FLUOROPHENOL