N-Methylpropionamide Chemical Properties

Melting point:

-43 °C (lit.)

Boiling point:

146 °C/90 mmHg (lit.)

Density 

0.931 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.436(lit.)

Flash point:

222 °F

pka

16.61±0.46(Predicted)

form 

clear liquid

color 

Colorless

Specific Gravity

0.93

BRN 

1737640

CAS DataBase Reference

1187-58-2(CAS DataBase Reference)

NIST Chemistry Reference

Propanamide, N-methyl-(1187-58-2)

EPA Substance Registry System

Propanamide, N-methyl- (1187-58-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

UE4515000

F 

3

HS Code 

2924.19.8000

MSDS

• Language:English Provider:N-Methylpropionamide
• Language:English Provider:SigmaAldrich

N-Methylpropionamide Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

N-Methylpropionamide has been used to investigate amide-induced phase separation of hexafluoro-2-propanol-water mixtures.

Purification Methods

The amide is a colourless, odourless, neutral liquid at room temperature with a high dielectric constant. The amount of water present can be determined directly by Karl Fischer titration, GLC and NMR have been used to detect unreacted propionic acid. Commercial material of high quality is available, probably from the condensation of anhydrous methylamine with 50% excess of propionic acid. Rapid heating to 120-140o with stirring favours the reaction by removing water either directly or as the ternary xylene azeotrope. The quality of the distillate improves during the distillation. N-Methylpropionamide can be dried over CaO. Water and unreacted propionic acid are removed as their xylene azeotropes. It is then distilled in a vacuum. Material used as an electrolyte solvent (specific conductance less than 10-6 ohm-1 cm -1) is obtained by fractional distillation under reduced pressure, and storage over BaO or molecular sieves because it readily absorbs moisture from the atmosphere on prolonged storage. [Hoover Pure Appl Chem 37 581 1974, Recommended Methods for Purification of Solvents and Tests for Impurities, Coetzee Ed., Pergamon Press, 1982, Beilstein 4 IV 183.]

N-Methylpropionamide(1187-58-2)Related Product Information

• L-LEUCYL-L-ALANINE
• Aspartame
• Panthenol
• 3-AMINO-1-PHENYL-2-PYRAZOLIN-5-ONE
• Calcium D-Pantothenate
• 4'-Chloroacetoacetanilide
• N-CYANOACETYLURETHANE
• PICROLONIC ACID
• 2-BENZOYLACETANILIDE
• 4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid
• 4-BENZOYL-3-METHYL-1-PHENYL-5-PYRAZOLINONE
• H-GAMMA-GLU-GLU-OH
• Sodium D-pantothenate
• ACID YELLOW 76 (C.I. 18850)
• N,N,2-TRIMETHYLPROPIONAMIDE
• Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-
• 3,3'-dithiobis[N-methylpropionamide]
• Vamidothion