3-Ethyl-4-methyl-3-pyrrolin-2-one Chemical Properties

Melting point:

100-104 °C (lit.)

Boiling point:

279.0±23.0 °C(Predicted)

Density 

0.977±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

powder to crystal

pka

14.44±0.60(Predicted)

color 

White to Almost white

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

766-36-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

22-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29337900

MSDS

• Language:English Provider:SigmaAldrich

3-Ethyl-4-methyl-3-pyrrolin-2-one Usage And Synthesis

Uses

3-Ethyl-4-methyl-3-pyrrolin-2-one is used as an intermediate for the manufacture of medicines. It is used for the preparation of Glimepiride (G410150), and its intermediates and as antidiabetic agents.

General Description

3-Ethyl-4-methyl-3-pyrrolin-2-one, a five-membered α,β-unsaturated lactam derivative, has various applications in medicinal chemistry. It can be synthesized by employing following as starting materials:

• allylamine, via palladium(II)-assisted cyclization
• 4-methoxybenzylamine, via a ring-closing-metathesis strategy
• 3-ethyl-1-(4-methoxybenzyl)-4-methyl-1,5-dihydro-2H-pyrrol-2- one

3-Ethyl-4-methyl-3-pyrrolin-2-one(766-36-9)Related Product Information

• 2-Methyl-4-isothiazolin-3-one
• Methylparaben
• Methyl acrylate
• Tribenuron methyl
• Pyrrole
• Basic Violet 1
• Kresoxim-methyl
• N-Methyl-2-pyrrolidone
• METSULFURON METHYL
• Methanol
• Methyl salicylate
• 3-Ethyl-2-hydroxy-2-cyclopenten-1-one
• Methyl
• AZINPHOS-METHYL
• Glimepiride
• 3,4,5,6-Tetrahydrophthalimide
• N-Hydroxymethyl-3,4,5,6-tetrahydrophthalimide
• Tetramethrin