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4,4'-DIMETHOXYCHALCONE

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4,4'-DIMETHOXYCHALCONE Basic information

Product Name:
4,4'-DIMETHOXYCHALCONE
Synonyms:
  • 1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE
  • 2-Propen-1-one, 1,3-bis(4-methoxyphenyl)-
  • Ai3-25492
  • Nsc 87339
  • 4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE
  • DIMETHOXYCHALCONE,4,4'-
  • (E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE
  • 4,4'-Dimethoxychalcone,99%
CAS:
2373-89-9
MF:
C17H16O3
MW:
268.31
Product Categories:
  • Chalcones
Mol File:
2373-89-9.mol
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4,4'-DIMETHOXYCHALCONE Chemical Properties

Melting point:
101°C
Boiling point:
444.6±45.0 °C(Predicted)
Density 
1.128±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 250 mg/mL (931.76 mM)
form 
Solid
color 
Light yellow to yellow
BRN 
1622293
CAS DataBase Reference
2373-89-9(CAS DataBase Reference)
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Safety Information

HS Code 
29145090

MSDS

  • Language:English Provider:ALFA
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4,4'-DIMETHOXYCHALCONE Usage And Synthesis

Uses

4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties[1].

in vivo

The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species[1].
? 4,4'-Dimethoxychalcone (100?mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice[1].

Animal Model:6-week-old male wild type C57BL/6 or Atg4b-/- mice[1]
Dosage:100?mg/kg
Administration:Injected intraperitoneally with a single
Result:Triggered autophagic flux in the heart and liver.

References

[1] Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. DOI:10.1038/s41467-019-08555-w

4,4'-DIMETHOXYCHALCONESupplier

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cfzhang@aikonchem.com
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