VENTURICIDIN A Chemical Properties

Melting point:

145-147°; mp 140-142°

alpha 

D +119° (c = 0.5 in chloroform)

Boiling point:

874.9±65.0 °C(Predicted)

Density 

1.16±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble

pka

11.80±0.70(Predicted)

form 

White to off-white solid.

color 

White to off-white

Safety Information

RTECS 

YX4556000

HS Code 

2941900000

VENTURICIDIN A Usage And Synthesis

Description

Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces. It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants. Venturicidin A is also cytotoxic against trypanosomes (IC₅₀ = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells. It inhibits bacterial and mitochondrial ATP synthases.

Uses

The macrolide antibiotic, Venturicidin A, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent.

Uses

Venturicidin A is an antibiotic and potent inhibitor of mitochondrial ATP synthase.

Definition

ChEBI: Venturicidin a is a diterpene lactone.

IC 50

Aminoglycoside

References

[1] A. RHODES. Venturicidin: A New Antifungal Antibiotic of Potential Use in Agriculture[J]. Nature, 1961, 192 4806: 952-954. DOI: 10.1038/192952a0
[2] DAVID S. PERLIN  Alan E S  Lisa R Latchney. Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin[J]. Biochimica et Biophysica Acta-Bioenergetics, 1985, 807 3: Pages 238-244. DOI: 10.1016/0005-2728(85)90254-3
[3] A MATSUNO-YAGI  Y H. Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds.[J]. The Journal of Biological Chemistry, 1993, 268 9: 6168-6173.

VENTURICIDIN A(33538-71-5)Related Product Information

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• N-PROPYLCARBAMATE
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• Methyl (R)-(-)-3-hydroxybutyrate
• TRANS-2-DODECEN-1-OL
• 2-HEPTEN-4-OL
• TRANS-2-UNDECEN-1-OL
• 2-(ALLYLOXY)TETRAHYDROPYRAN