N-PROPYLCARBAMATE Chemical Properties

Melting point:

61-63 °C(lit.)

Boiling point:

92-93 °C/12 mmHg(lit.)

Density 

0.9809 (estimate)

refractive index 

1.4228 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

13.54±0.50(Predicted)

color 

White to Off-White

Water Solubility 

200.1g/L(37 ºC)

IARC

3 (Vol. 12, Sup 7) 1987

EPA Substance Registry System

Propyl carbamate (627-12-3)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

RTECS 

FD0875000

HS Code 

2924190090

Hazardous Substances Data

627-12-3(Hazardous Substances Data)

N-PROPYLCARBAMATE Usage And Synthesis

Chemical Properties

White Solid

Uses

A metabolite of alkyl carbamate (ethyl or propyl).

Definition

ChEBI: N-Propyl carbamate is a carbamate ester.

Safety Profile

Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Questionable carcinogen with experimental neoplas tigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES.

Synthesis

1. Catalyst preparation: The catalyst was prepared by calcining La(NO3)3-6H2O in air at 350 °C for 4 hours. 2. Preparation of reactants: 48.0 g of n-propanol, 6.0 g of urea, and 0.8 g (13.3% of the mass of urea) of the above-prepared catalyst were added to the autoclave. 3. Reaction conditions: The reaction was carried out at 180 °C for 6 h under autogenous pressure (ca. 12.2 atm). 4. 4. Product analysis: At the end of the reaction, the yields of dipropyl carbonate (DPC) and propyl carbamate (PC) were 54.2% by weight and 18.3% by weight, respectively.

References

[1] Patent: US2010/312001, 2010, A1. Location in patent: Page/Page column 3

N-PROPYLCARBAMATE(627-12-3)Related Product Information

• Fmoc-Cys(tBu)-OH
• 2-METHYL-2-(1-METHYLPROPYL)-1,3-PROPANEDIOL DICARBAMATE
• (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE
• Lorbamate
• FMOC-PHE-OH
• Fmoc-Pro-OH
• (R)-4-Benzyl-2-oxazolidinone
• Isobutyl 1,2-dihydro-2-isobutoxy-1-quinoline-carboxylate
• FMOC-O-tert-Butyl-L-serine
• Nalpha-FMOC-L-Tryptophan
• (4S)-(-)-4-Isopropyl-2-oxazolidinone
• Fmoc-Ile-OH
• n-Butyl carbamate
• Fmoc-Tyr(tBu)-OH
• FMOC-L-Valine
• PROPYL-3-(DIMETHYLAMINO)PROPYLCARBAMATE
• 1-Chloroethyl isopropyl carbonate
• ETHYL 3-(TRIETHOXYSILYL)PROPYLCARBAMATE