5-BROMO-2-METHOXYBENZYL ALCOHOL Chemical Properties

Melting point:

68-71 °C (lit.)

Boiling point:

192.5°C (rough estimate)

Density 

1.4816 (rough estimate)

refractive index 

1.4930 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Light yellow

CAS DataBase Reference

80866-82-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-22

Safety Statements 

37/39-26-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29094990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

5-BROMO-2-METHOXYBENZYL ALCOHOL Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

5-Bromo-2-methoxybenzyl alcohol has been used in the synthesis of 5-bromo-2-methoxyphenylacetic acid.

Synthesis

GENERAL METHODS: Lithium bromide monohydrate (0.2 mmol) and iodobenzene diacetate (0.2 mmol) were added to a solution of 2-methoxybenzenemethanol (0.2 mmol) in trifluoroethanol (1 mL) and the reaction was carried out at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium sulfite solution. The mixture was extracted with dichloromethane and the combined organic layers were washed with saturated brine and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to afford the target product 5-bromo-2-methoxybenzyl alcohol.

References

[1] Synlett, 2018, vol. 29, # 17, p. 2275 - 2278
[2] Tetrahedron Letters, 2000, vol. 41, # 46, p. 8881 - 8885
[3] Synthetic Communications, 2007, vol. 37, # 9, p. 1571 - 1577

5-BROMO-2-METHOXYBENZYL ALCOHOL(80866-82-6)Related Product Information

• 5-BROMO-2-METHOXYPHENYLACETIC ACID
• 5-BROMO-2-METHOXY-NICOTINIC ACID
• 5-Bromo-2-methoxybenzoic acid
• 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID
• Acid Red 92
• METHYL 3,5-DIBROMO-2,4-DIMETHOXY-6-METHYLBENZOATE
• 3-BROMO-2,6-DIMETHOXYBENZOIC ACID
• Bromopyrogallol Red
• 5-BROMO-2-METHOXYBENZYL ALCOHOL
• 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN
• Acid Red 87
• 4-BROMO-2-METHOXYBENZYL ALCOHOL 97
• 2-Methoxybenzyl alcohol
• EOSIN
• EOSIN 5-ISOTHIOCYANATE
• TETRACHROME STAIN
• 3,5-DIBROMO-2-METHOXYBENZOIC ACID
• AZUR C EOSINATE