METHYL-D3-MALONIC ACID Chemical Properties

Melting point:

134-136 °C(lit.)

Flash point:

2 °C

storage temp. 

-20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Safety Information

Hazard Codes 

Xn,F

Risk Statements 

20/22-36/37/38-36-20/21/22-11

Safety Statements 

26-36-36/37-16

RIDADR 

UN 1648 3 / PGII

WGK Germany 

3

MSDS

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METHYL-D3-MALONIC ACID Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

An isotope labelled derivative of Methylmalonic Acid (M318860), binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

Uses

Methyl-d3-malonic acid is an isotope labelled derivative of Methylmalonic Acid (M318860), binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-depend ent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

General Description

Methylmalonic acid, a malonic acid derivative, is a vital intermediate in the metabolism of fat and proteins and plays a key role in energy metabolism. Elevated methylmalonic acid levels can be caused by an inborn error of metabolism leading to methylmalonic aciduria or indicate early vitamin B₁₂ deficiency. This internal standard is suitable for quantitation of methylmalonic acid levels by LC/MS or GC/MS in newborn screening and clinical testing applications to test for methylmalonic acidemia and diagnose vitamin B₁₂ deficiency.

METHYL-D3-MALONIC ACID(42522-59-8)Related Product Information

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• PROPIONIC-3,3,3-D3 ACID
• 2-METHYL-D3-PROPYL ALCOHOL
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