5-Hydroxy-2-nitrobenzoic acid Chemical Properties

Melting point:

170-171°C

Boiling point:

455.0±40.0 °C(Predicted)

Density 

1.631

RTECS 

DH2528250

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

2.06±0.25(Predicted)

color 

White to Yellow to Green

CAS DataBase Reference

610-37-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

Hazard Note 

Irritant

HS Code 

29163990

5-Hydroxy-2-nitrobenzoic acid Usage And Synthesis

Uses

5-Hydroxy-2-nitrobenzoic acid inhibits the activity of wild type-bovine low Mr protein tyrosine phosphatase. The inhibition constant has been evaluated.

Synthesis

General procedure for the synthesis of 2-nitro-5-hydroxybenzoic acid from 5-chloro-2-nitrobenzoic acid: 5-chloro-2-nitrobenzoic acid (32.00 g, 0.159 mol) was dissolved in 15% aqueous sodium hydroxide solution and reacted at reflux under nitrogen protection for 72 hours. After completion of the reaction, the pH of the reaction solution was adjusted to 1.0 with dilute hydrochloric acid and then extracted with ethyl acetate. The ethyl acetate extracts were combined and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 28.05 g of 2-nitro-5-hydroxybenzoic acid in 96.5% yield.

References

[1] Chemistry - A European Journal, 2013, vol. 19, # 43, p. 14654 - 14664
[2] Patent: CN106478548, 2017, A. Location in patent: Paragraph 0019-0020; 0035-0036; 0051-0052; 0067-0068
[3] Patent: US2017/158680, 2017, A1. Location in patent: Paragraph 0330; 0331; 0332
[4] Patent: WO2003/97641, 2003, A2. Location in patent: Page/Page column 63
[5] Patent: US4348396, 1982, A

5-Hydroxy-2-nitrobenzoic acid(610-37-7)Related Product Information

• 5-Hydroxy-2-nitrobenzaldehyde
• Ethyl 2-(Chlorosulfonyl)acetate
• Salicylic acid
• 3-Hydroxybenzoic acid
• Butylparaben
• CHLOROPHOSPHONAZO III
• 4-Nitrobenzoic acid
• 4-Hydroxybenzoic acid
• 2-Nitrobenzoic acid
• Methylparaben
• Ascoric Acid
• 3-HYDROXY-2-NITROBENZOIC ACID,3-HYDROXY-2-NITROBENZOIC ACID, 98+%
• 5-(2-Chloro-4-(trifluoro-methyl)phenoxy)-2-nitro-benzoic acid sodium salt
• METHYL 5-METHOXY-2-NITROBENZOATE
• ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE
• 5-Methoxy-2-nitrobenzoic acid
• Methyl 4,5-dimethoxy-2-nitrobenzoate
• D-ribo-Hexanoic acid, 3-deoxy-, γ-lactone