(R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties

Melting point:

48-52 °C(lit.)

Boiling point:

185-195 °C(Press: 0.5 Torr)

alpha 

D23 +104° (c = 0.88 in benzene)

Density 

1.218±0.06 g/cm3(Predicted)

refractive index 

114 ° (C=1, EtOH)

Flash point:

>230 °F

storage temp. 

-20°C

solubility 

Acetonitrile (Slightly), Chloroform (Slightly), DMSO

form 

Solid

pka

5.4(at 25℃)

color 

Light Yellow to Yellow

optical activity

[α]20/D +104°, c = 1 in chloroform

Merck 

14,9326

LogP

2.160 (est)

CAS DataBase Reference

1200-22-2(CAS DataBase Reference)

Safety Information

Risk Statements 

22-36/38

Safety Statements 

20-36-26-35

WGK Germany 

3

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis

Chemical Properties

Yellow Crystalline Solid

Uses

A fat-metabolism stimulator

Uses

α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.

Definition

ChEBI: (R)-lipoic acid is the (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties. It has a role as a prosthetic group, a nutraceutical and a cofactor. It is a lipoic acid, a member of dithiolanes, a heterocyclic fatty acid and a thia fatty acid. It is functionally related to an octanoic acid. It is a conjugate acid of a (R)-lipoate. It is an enantiomer of a (S)-lipoic acid.

General Description

α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.

Biochem/physiol Actions

(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.

(R)-(+)-1,2-Dithiolane-3-pentanoic acid(1200-22-2)Related Product Information

• DL-1,2-DITHIOLANE-3-PENTANOIC ACID REDUCED FORM
• α-Lipoic Acid
• Lipoic acid tromethamine salt
• (R)-6,8-Dimercaptooctanoic acid
• Sodium thioctate
• OCTOTIAMINE
• 1,2,3-Trithiane-4-pentanoic Acid
• Lipoic Acid Related CoMpound
• rac α-Lipoic Acid-d5
• R-Lipoic Acid Impurity 1 (S-Oxide)
• Sodium (R)-alpha-lipoate
• R-alpha-Lipoic acid tromethamine salt
• 1,2-Dithiolane-3-pentanoic acid
• 1,2-Dithiolane-3-pentanoic acid 1-oxide
• (S)-1,2-Dithiolane-3-pentanoic acid,1,2-Dithiolane-3-pentanoic acid, (S)-,1,2-Dithiolane-3-pentanoic acid, (3S)- (9CI)
• DL-1,2-DITHIOLANE-3-PENTANOIC ACID
• (+/-)-1,2-Dithiolane-3-pentanoic Acid-d5
• (R)-1,2-Dithiolane-3-pentanoic acid polymer with 2-hydroxypropanoic ac id