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ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and Derivatives >  Other amino acid derivatives >  L-NIO DIHYDROCHLORIDE

L-NIO DIHYDROCHLORIDE

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L-NIO DIHYDROCHLORIDE Basic information

Product Name:
L-NIO DIHYDROCHLORIDE
Synonyms:
  • L-NIO
  • L-NIO, 2HCL
  • n(g)-iminoethylornithine
  • NG-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE
  • N5-(1-IMINOETHYL)-L-ORNITHINE DIHYDROCHLORIDE
  • N(5)-(1-IMINOETHYL)-L-ORNITHINE HCL
  • N5-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE
  • L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORI DE POTENT IRREVERSIBLE N
CAS:
36889-13-1
MF:
C7H15N3O2
MW:
173.21
Product Categories:
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Nitric Oxide Reagents
  • Nitric Oxide
Mol File:
36889-13-1.mol
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L-NIO DIHYDROCHLORIDE Chemical Properties

Melting point:
225-226°C
storage temp. 
-20°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Safety Information

Safety Statements 
24/25
HS Code 
29224985

MSDS

  • Language:English Provider:ACROS
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L-NIO DIHYDROCHLORIDE Usage And Synthesis

Description

L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.

Chemical Properties

White Crystalline Solid

Uses

A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

Definition

ChEBI: L-NIO is a L-alpha-amino acid.

Biological Activity

Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .

L-NIO DIHYDROCHLORIDESupplier

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