L-NIO DIHYDROCHLORIDE Chemical Properties

Melting point:

225-226°C

storage temp. 

-20°C

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

H2O: 2mg/mL, clear (warmed)

Stability:

Hygroscopic

Safety Information

Safety Statements 

24/25

HS Code 

29224985

MSDS

• Language:English Provider:ACROS

L-NIO DIHYDROCHLORIDE Usage And Synthesis

Description

L-NIO is a non-selective inhibitor of all NOS isoforms. The K_i values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.

Chemical Properties

White Crystalline Solid

Uses

A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

Definition

ChEBI: L-NIO is a L-alpha-amino acid.

Biological Activity

Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .

References

[1] B R BABU  O W G. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase.[J]. The Journal of Biological Chemistry, 1998, 273 15: 8882-8889. DOI: 10.1074/jbc.273.15.8882

L-NIO DIHYDROCHLORIDE(36889-13-1)Related Product Information

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