Methyltetrazine-amido-PEG5-alkyne
Methyltetrazine-amido-PEG5-alkyne Basic information
- Product Name:
- Methyltetrazine-amido-PEG5-alkyne
- Synonyms:
-
- Methyltetrazine-amido-PEG5-alkyne
- N-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzyl)-4,7,10,13,16-pentaoxanonadec-18-ynamide
- N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]-3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]propanamide
- 4,7,10,13,16-Pentaoxanonadec-18-ynamide, N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]-
- CAS:
- 2322322-23-4
- MF:
- C24H33N5O6
- MW:
- 487.55
- Mol File:
- 2322322-23-4.mol
More
Less
Methyltetrazine-amido-PEG5-alkyne Chemical Properties
- Density
- 1.181±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 14.29±0.46(Predicted)
- form
- Solid
- color
- Purple to purplish red
More
Less
Methyltetrazine-amido-PEG5-alkyne Usage And Synthesis
Description
Methyltetrazine-amido-PEG5-alkyne is a heterobifunctional crosslinker. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule under mild condition. The alkynes is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry. PEG5 space increase the compound's aqueous solubility.
Uses
Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Methyltetrazine-amido-PEG5-alkyneSupplier
Xi'an Confluore Biological Technology Co., Ltd.
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
Henan's chemical products co., LTD
- Tel
- 0371-60919097 15378766539
- 794449696@qq.com
Alfa Chemistry
- Tel
- +1-5166625404;
- Info@alfa-chemistry.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Shanghai Haohong Pharmaceutical Co., Ltd.
- Tel
- 400-8210725 4008210725
- malulu@leyan.com