Methyltetrazine-Acid Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: 100 mg/mL (434.37 mM)

form 

Solid

color 

Pale purple to purple

InChI

InChI=1S/C11H10N4O2/c1-7-12-14-11(15-13-7)9-4-2-8(3-5-9)6-10(16)17/h2-5H,6H2,1H3,(H,16,17)

InChIKey

TZNOWMYISKGWCY-UHFFFAOYSA-N

SMILES

C1(CC(O)=O)=CC=C(C2=NN=C(C)N=N2)C=C1

Methyltetrazine-Acid Usage And Synthesis

Description

Methyltetrazine-Acid is a stable click chemistry building block. In the presence of activators (e.g. EDC, or HATU), it can be used to deriviate amine-containing molecule via a stable amide bond. Methyltetrazine enable fast click chemistry with TCO ((trans-cycloctene) under mild condition

Uses

Methyltetrazine-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Alkyl-Chain

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methyltetrazine-Acid(1380500-88-8)Related Product Information

• Methyltetrazine-PEG8-NHS ester
• Methyltetrazine-amido-PEG5-alkyne
• Methyltetrazine-PEG4-Azide
• Methyltetrazine-PEG12-NHS ester
• Methyltetrazine-NHS Ester
• Me-Tetrazine-PEG1-Alkyne
• Phosphonic acid,P-[(6-?methyl-?1,?2,?4,?5-?tetrazin-?3-?yl)?methyl]?-,diethyl ester