Methyltetrazine-PEG4-Azide Chemical Properties

solubility 

Soluble in DMSO, DMF, DCM

Methyltetrazine-PEG4-Azide Usage And Synthesis

Description

Methyltetrazine-PEG4-azide is a herterobifunctional click chemistry reagent containing a methyltetrazine and azide moiety. The azide group can participate in copper-catalyzed Click Chemistry reactions with reagents such as alkynes, DBCO and BCN to form triazole moieties. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene)

Uses

Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methyltetrazine-PEG4-Azide(1802908-04-8)Related Product Information

• Me-Tet-PEG4-NH2
• TAMRA azide, 6-isomer
• PEP azide
• Cy5.5 Azide
• Biotin-PEG2-C6-Azide
• picolyl-azide-Acid
• Cy3 azide
• 6-Azido-hexanoic acid
• Cy5 Azide
• Desthiobiotin-PEG4-Alkyne
• Methyltetrazine-NHS Ester
• N-[2-[2-[2-[2-(Aminooxy)ethoxy]ethoxy]ethoxy]ethoxy]-4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetamide
• Dde Biotin-PEG4-Azide
• Dde Biotin-PEG4-Alkyne
• Methyltetrazine-PEG12-NHS ester
• Methyltetrazine-amido-PEG5-alkyne
• Methyltetrazine-PEG8-NHS ester
• Azidoacetic acid