METHYL 3-AMINO-4-FLUOROBENZENECARBOXYLATE Chemical Properties

Melting point:

66-69

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

crystalline solid

color 

Beige

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2922498590

METHYL 3-AMINO-4-FLUOROBENZENECARBOXYLATE Usage And Synthesis

Synthesis

Step B: Synthesis of methyl 3-amino-4-fluorobenzoate; Methyl 4-fluoro-3-nitrobenzoate (6.57 g, 33 mmol) was dissolved in EtOAc (75 mL) and 10% palladium carbon catalyst (0.66 g) was added. The reaction mixture was transferred to a Fisher-Porter flask and mounted on a hydrogenation unit. The flask was charged with hydrogen (25 psi) and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad, followed by concentration of the filtrate to give a yellow oily product which deepened in color on standing and in quantitative yield (5.51 g, 33 mmol). Mass spectrometry (ESI) showed m/z = 170 [M + H]+.

References

[1] Patent: WO2009/76140, 2009, A1. Location in patent: Page/Page column 186
[2] Journal of Organic Chemistry, 1990, vol. 55, # 7, p. 2034 - 2044
[3] Synlett, 2010, # 20, p. 3019 - 3022
[4] Patent: WO2010/126922, 2010, A1. Location in patent: Page/Page column 62
[5] Zhurnal Organicheskoi Khimii, 1972, vol. 8, p. 803,804; engl. Ausg. S. 813, 814

METHYL 3-AMINO-4-FLUOROBENZENECARBOXYLATE(369-26-6)Related Product Information

• 2,6-Dioxopiperidine-3-ammonium chloride
• 3-AMINO-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER
• 3-AMINO-2-PIPERIDINONE HYDROCHLORIDE
• METHYL 4-AMINO-3-FLUOROBENZENECARBOXYLATE
• methyl 4-fluoro-3-(3-oxobutanamido)benzoate
• Methyl 5-amino-2,4-difluorobenzoate
• METHYL 3-AMINO-4-FLUOROBENZENECARBOXYLATE
• METHYL 2-CHLORO-4-FLUORO-5-NITROBENZOATE
• Methyl 4-fluoro-3-nitrobenzoate
• 2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER
• 4-FLUORO-3-NITROMETHYLBENZOATE, [CARBONYL-14C]-
• Ethyl 3-amino-4-fluorobenzoate