Quinapril hydrochloride Chemical Properties

Melting point:

120-130°C

alpha 

D23 +14.5° (c = 1.2 in ethanol) (Klutchko); D25 +15.4° (c = 2 in methanol) (Goel, Krolls)

storage temp. 

2-8°C

solubility 

H2O: >10mg/mL

form 

solid

color 

white

CAS DataBase Reference

82586-55-8(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

2

RTECS 

NW7176000

HS Code 

2933492250

Hazardous Substances Data

82586-55-8(Hazardous Substances Data)

Toxicity

Freely sol in aq solvents. LD50 in male, female mice, rats (mg/kg): 1739, 1840, 4280, 3541 orally; 504, 523, 158, 107 i.v. (Kaplan, 1989)

Quinapril hydrochloride Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

Antihypertensive;Dopamine receptor agonist

Uses

Quinapril is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Uses

Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.

Definition

ChEBI: Quinapril hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a quinapril(1+).

brand name

Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) .

General Description

Quinapril hydrochloride,(S)-[(S)-N-[(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hydrochloride(Acuretic), forms the diacid quinaprilate in thebody. It is more potent than captopril and equipotent to theactive form of enalapril.

Biochem/physiol Actions

Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.

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