5-Bromo-2-furaldehyde Chemical Properties

Melting point:

82-85 °C (lit.)

Boiling point:

112 °C/16 mmHg (lit.)

Density 

1.5940 (rough estimate)

refractive index 

1.4450 (estimate)

Flash point:

112°C/6mm

storage temp. 

2-8°C

solubility 

Chloroform, Methanol

form 

Powder

color 

Slightly yellow

Sensitive 

Air Sensitive

BRN 

108403

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

1899-24-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36-36/37/39

WGK Germany 

3

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

29130000

MSDS

• Language:English Provider:5-Bromo-2-furaldehyde
• Language:English Provider:SigmaAldrich
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5-Bromo-2-furaldehyde Usage And Synthesis

Chemical Properties

solid

Physical properties

5-Bromo-2-furfuraldehyde is a light yellow powder, soluble in carbon dichloride , carbon tetrachloride, ether and other organic solvents.

Uses

5-Bromo-2-furaldehyde is used in the preparation of isoindolinones from furfural. Also used in the preparation of brominated nitrovinylfuran which displays antibacterial activity.

Uses

5-Bromo-2-furaldehyde may be employed for the following syntheses:

• 5-substituted 2-furaldehydes
• anilines, through a novel one-pot, two-step amination/Diels-Alder procedure
• 5-(5′,8′-dimethyl-9′-tert-butoxycarbonyl-9′H-carbazol-3′-yl)-furan-2-carbaldehyde
• 5-(6-hydroxyhexyl)-2-furaldehyde
• 5-methylsulfonyl-2-furaldehyde
• 5-phenylsulfonyl-2-furaldehyde
• 5-(4-acetamidobenzylsulfonyl)-2-furaldehyde
• 5-iodo-2-furaldehyde

Preparation

A three-necked 50 mL round bottom flask was charged with [bmim]Br3 (20 mmol) followed by dropwise addition of freshly distilled 2-furfural (20 mmol) over a period of 0.5 h and the reaction mixture was stirred for at 40 ℃ 2.5 h under nitrogen atmosphere. The mixture was extracted with petroleum ether (30 mL × 3), the organic layer was washed with water, dried (sodium sulfate) and concentrated. The crude product was purified by distillation and recrystallization with 10 % ethyl acetate-ether solution.
5-Bromo-2-furfural of yellowish crystal in 88 % yield was obtained. Mp. 82-85 ℃, 1H NMR (CDCl3), δ: 9.55 (s, 1H), 7.25 (s, 1H), 6.57 (s, 1H).

5-Bromo-2-furaldehyde(1899-24-7)Related Product Information

• Furfural
• 5-Bromo-1-benzofuran
• 3-Furaldehyde
• FURFURYL ALCOHOL RESIN
• Furazolidone
• 5-Bromothiophene-2-carbaldehyde
• Formaldehyde
• Tetrahydrofuran
• 2-Bromo-5-nitropyridine
• Bromine
• 2,3-Dibromofuran-5-carboxylic acid
• METHYL 5-BROMO-2-FUROATE
• 5-Bromofuroic acid
• 4,5-Dibromo-2-furaldehyde
• 4-BROMO-2-FURALDEHYDE,4-Bromo-2-furaldehyde(4-Bromofurfural),4-BROMO-2-FURALDEHYDE 95+%
• CHEMBRDG-BB 5245988
• N-(1,3-benzodioxol-5-yl)-5-bromo-2-furamide
• N-(4-Acetylphenyl)-5-bromo-2-furamide