1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE CAS#: 65513-72-6

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1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE

Basic information Safety Supplier Related

1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE Basic information

Product Name:

1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE

Synonyms:

GlafenineHCl
Glafenin hydrochloride
GLAFENINE HYDROCHLORIDE
1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE
2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate hydrochloride
inhibit,Glafenine Hydrochloride,Glafenine,Glafenin,Inhibitor

CAS:

65513-72-6

MF:

C19H18Cl2N2O4

MW:

409.26

Mol File:

65513-72-6.mol

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1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE Chemical Properties

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO : ≥ 60 mg/mL (146.61 mM)
form: Solid
color: Light yellow to yellow
Major Application: forensics and toxicology
pharmaceutical (small molecule)
InChI: 1S/C19H17ClN2O4.ClH/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23;/h1-9,13,23-24H,10-11H2,(H,21,22);1H
InChIKey: CEUMONXVSJOJIH-UHFFFAOYSA-N
SMILES: Cl.OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23

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Safety Information

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: CB2687000
Storage Class: 11 - Combustible Solids

MSDS

Language:English Provider:SigmaAldrich

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1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE Usage And Synthesis

Uses

Analgesic

in vivo

Glafenine injection (25 mg/kg i.v.) shows enhanced BLI signal in mice with an average of 2.9-fold signal enhancement over the control. Glafenine causes increases in BLI signal of up to 11.6- and 17.4-fold in two separate HEK293/ABCG2/fLuc xenografts in the same mouse compared to the signals generated by those xenografts immediately before injection^[1]. Incubating polarized CFBE41o^- monolayers and intestines isolated from mutant CFTR mice with glafenine increases the short-circuit current response to forskolin and genistein. Treatment with glafenine also partially restores total salivary secretion^[2]. Glafenine-treated zebrafish shows evidence of endoplasmic reticulum and mitochondrial stress, with disrupted intestinal architecture and halted cell stress responses, alongside accumulation of apoptotic intestinal epithelial cells in the lumen^[4].

1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDESupplier

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com

MedChemexpress LLC

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Email: sales@medchemexpress.cn

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Email: sales@zehanbiopharma.com

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Email: 3008007409@qq.com

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Email: sales@uhnshanghai.com

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