Larazotide Chemical Properties

Density 

1.254

storage temp. 

Store at -20°C

solubility 

DMSO: Insoluble;Ethanol: Insoluble

form 

Solid

color 

White to off-white

Water Solubility 

Water: 25 mg/mL (34.44 mM)

Sequence

H-Gly-Gly-Val-Leu-Val-Gln-Pro-Gly-OH

Larazotide Usage And Synthesis

Uses

Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection[1][2].

Definition

ChEBI: Larazotide is an oligopeptide.

in vivo

References

[1] Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22(17):9427. DOI:10.3390/ijms22179427
[2] Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94. DOI:10.1016/j.peptides.2012.02.015

Larazotide(258818-34-7)Related Product Information

• Boc-D-Glutamine
• L-Alanyl-L-Glutamine
• Transglutaminase
• Sincalide
• OLIGOPEPTIDE-34
• Glycyl-L-arginylglycyl-L-alpha-aspartyl-L-tyrosyl-L-isoleucyl-L-tryptophyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-threonyl-L-glutamine
• PALMITOYL TETRAPEPTIDE-3
• HEXAPEPTIDE-2
• Hexapeptide-33
• Tirzepatide
• Calcitonin salmon
• GLP-1 (7-37)
• NONAPEPTIDE-1
• L-Cysteine, L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-threonyl-L-prolyl-L-α-glutamylglycyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1→17)-disulfide
• OLIGOPEPTIDE-50
• Riluzole
• L-Glutamine
• Larazotide