2-Methylindoline Chemical Properties

Melting point:

-51 °C

Boiling point:

228-229 °C (lit.)

Density 

1.023 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.569(lit.)

Flash point:

200 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform, Methanol

form 

Liquid

pka

5.26±0.40(Predicted)

Specific Gravity

1.02

color 

Clear yellow to brown

Water Solubility 

negligible

CAS DataBase Reference

6872-06-6(CAS DataBase Reference)

NIST Chemistry Reference

2-Methylindoline(6872-06-6)

EPA Substance Registry System

1H-Indole, 2,3-dihydro-2-methyl- (6872-06-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-52/53-22

Safety Statements 

26-36/37/39-60-57

WGK Germany 

3

RTECS 

NM1926350

Hazard Note 

Irritant

HS Code 

29349990

MSDS

• Language:English Provider:2-Methylindoline
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

2-Methylindoline Usage And Synthesis

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Uses

2-Methylindoline is an intermediate in the production of various indole derivatives

Uses

Reactant for preparation of:

• Inhibitors of NOD1-induced nuclear factor-κB activation
• Red fluorescent dyes for organic light-emitting diodes
• Norepinephrine reuptake inhibitors
• MT2-selective melatonin receptor antagonists
• Protease-activated receptor-1 antagonists
• Diuretic agent indapamide
• Dopamine D2/D4 receptor antagonists
• Antitumor agents

Definition

ChEBI: 2-Methylindoline is a member of indoles.

Synthesis Reference(s)

Journal of the American Chemical Society, 111, p. 4108, 1989 DOI: 10.1021/ja00193a056
Chemical and Pharmaceutical Bulletin, 26, p. 108, 1978 DOI: 10.1248/cpb.26.108

2-Methylindoline(6872-06-6)Related Product Information

• 3-Methylindole
• Tetramethylammonium hydroxide
• Benzyltrimethylammonium hydroxide
• 2-Methylindole
• Poly(methylhydrosiloxane)
• Methyl tetrahydrophthalic anhydride
• cis-Octahydroisoindole
• Methylhexahydrophthalic anhydride
• 5-Methylindole
• 1-Methylindole
• Isoindoline
• Indoline
• 1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline
• IndapaMide iMpurity 5
• 4-Chloro-3-sulfamoylbenzoyl chloride
• INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS)
• (±)-2-methyl-1-nitrosoindoline
• 5-hydroxyindapamide