Ranolazine dihydrochloride
Ranolazine dihydrochloride Basic information
- Product Name:
- Ranolazine dihydrochloride
- Synonyms:
-
- (+/-)-4-[2-HYDROXY-3-(O-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETO-2',6'-XYLIDIDE DIHYDROCHLORIDE
- n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride
- (+/-)-N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE DIHYDROCHLORIDE
- RANOLAZINE DIHYDROCHLORIDE
- RANOLAZINE HCL
- Ranolazine DiHCI
- Ranolazine and salt
- N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide di
- CAS:
- 95635-56-6
- MF:
- C24H35Cl2N3O4
- MW:
- 500.46
- Product Categories:
-
- Active Pharmaceutical Ingredients
- Cardiovascular APIs
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Ranolazine
- Aromatics Compounds
- Pharmaceuticals
- Mol File:
- 95635-56-6.mol
Ranolazine dihydrochloride Chemical Properties
- Melting point:
- 222-229.5 °C(lit.)
- storage temp.
- Desiccate at RT
- solubility
- H2O: 10 mg/mL, soluble
- form
- solid
- color
- off-white
- Merck
- 14,8111
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 95635-56-6(CAS DataBase Reference)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- TK7845370
- HS Code
- 29335990
MSDS
- Language:English Provider:SigmaAldrich
Ranolazine dihydrochloride Usage And Synthesis
Description
Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .
Chemical Properties
White Crystalline Powder
Uses
Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.
Uses
treatment of angina and congestive heart failure
Biological Activity
Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.
Biochem/physiol Actions
Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.
storage
Desiccate at RT
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